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Anti-KPNA3 Antibody

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产品名称: Anti-KPNA3 Antibody
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简单介绍

Anti-KPNA3 Antibody


Anti-KPNA3 Antibody  的详细介绍
Name: Anti-KPNA3 Antibody
See all KPNA3 primary antibodies
Description: Goat polyclonal antibody to KPNA3.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human KPNA3 (C terminal).
Sequence: C-DPTANLQTKEFNF
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.
Tissue Specificity: Ubiquitous. Highest levels in heart and skeletal muscle.
Sequence Similarities: Belongs to the importin alpha family.
Cellular Location: Cytoplasm. Nucleus.
Database Links:
  • Entrez Gene: 3839 Human
  • Omim: 601892 Human
  • SwissProt: O00505 Human
  • Unigene: 527919 Human
    		•
    Synonyms:
  • SRP1 gamma Antibody
  • hSRP1 Antibody
  • IMA4_HUMAN Antibody
  • Importin alpha 3 Antibody
  • Importin alpha 3 subunit Antibody
  • Importin alpha 4 Antibody
  • Importin alpha Q2 Antibody
  • Importin subunit alpha-4 Antibody
  • IPOA4 Antibody
  • Karyopherin alpha 3 Antibody
  • Karyopherin alpha 3 importin alpha 4 Antibody
  • Karyopherin alpha 3 subunit Antibody
  • Karyopherin subunit alpha 3 Antibody
  • Karyopherin subunit alpha-3 Antibody
  • KPNA 3 Antibody
  • KPNA3 Antibody
  • Qip2 Antibody
  • SRP1 Antibody
  • SRP1-gamma Antibody
  • SRP1gamma Antibody
  • SRP4 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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