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Anti-c-Jun (phospho-S73) Antibody

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产品名称: Anti-c-Jun (phospho-S73) Antibody
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Anti-c-Jun (phospho-S73) Antibody


Anti-c-Jun (phospho-S73) Antibody  的详细介绍
Name: Anti-c-Jun (phospho-S73) Antibody
See all c-Jun primary antibodies
Description: Rabbit polyclonal antibody to c-Jun (phospho-S73)
Specificity: p-c-Jun (S73) pAb detects endogenous levels of c-Jun protein only when phosphorylated at Ser73.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic phosphopeptide derived from human c-Jun around the phosphorylation site of Serine 73.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 43, 48 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
Sequence Similarities: Belongs to the bZIP family. Jun subfamily.
Post-Translational Modification: Ubiquitinated by the SCF(FBXW7), leading to its degradation. Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 3725?Human
  • Entrez Gene: 16476?Mouse
  • Entrez Gene: 24516?Rat
  • Omim: 165160?Human
  • SwissProt: P05412?Human
  • SwissProt: P05627?Mouse
  • SwissProt: P17325?Rat
  • Unigene: 696684?Human
  • Unigene: 275071?Mouse
  • Unigene: 93714?Rat
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    Synonyms:
  • Activator protein 1 Antibody
  • AP 1 Antibody
  • AP1 Antibody
  • c-Jun Antibody
  • cJun Antibody
  • Enhancer Binding Protein AP1 Antibody
  • JUN Antibody
  • Jun Activation Domain Binding Protein Antibody
  • Jun oncogene Antibody
  • JUN protein Antibody
  • Jun proto oncogene Antibody
  • JUNC Antibody
  • JUN_HUMAN Antibody
  • Oncogene JUN Antibody
  • p39 Antibody
  • Proto oncogene c jun Antibody
  • Proto oncogene cJun Antibody
  • Proto-oncogene c-jun Antibody
  • Transcription Factor AP 1 Antibody
  • Transcription factor AP-1 Antibody
  • Transcription Factor AP1 Antibody
  • V jun avian sarcoma virus 17 oncogene homolog Antibody
  • V jun sarcoma virus 17 oncogene homolog Antibody
  • V jun sarcoma virus 17 oncogene homolog (avian) Antibody
  • V-jun avian sarcoma virus 17 oncogene homolog Antibody
  • vJun Avian Sarcoma Virus 17 Oncogene Homolog Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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