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Anti-alpha Fetoprotein Antibody

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产品名称: Anti-alpha Fetoprotein Antibody
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Anti-alpha Fetoprotein Antibody


Anti-alpha Fetoprotein Antibody  的详细介绍
Name: Anti-alpha Fetoprotein Antibody
See all alpha Fetoprotein primary antibodies
Description: Mouse monoclonal (AFP-01) antibody to alpha Fetoprotein.
Specificity: The antibody AFP-01 reacts with human alpha-Fetoprotein (AFP), a 70 kDa oncofetal antigen. AFP is a major fetal plasma protein, but is not present in healthy ***** tissues. Elevated AFP concentrations in ***** plasma may be an early marker of hepatocellular carcinoma or teratoblastoma, while high concentrations in amniotic fluid may indicate severe congenital defects of a fetus.
Applications: IP, ELISA, WB
Reactivity: Human
Immunogen: Purified alpha Fetoprotein.
Host: Mouse
Clonality: Monoclonal
Clone: AFP-01
Isotype: IgG1
Conjugate: Unconjugated
Purification: Purified from ascites by precipitation methods.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage: Store at 2-8°C.
Function: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.
Tissue Specificity: Plasma. Synthesized by the fetal liver and yolk sac.
Involvement in Disease: Alpha-fetoprotein deficiency: A benign condition characterized by undetectable AFP levels in the amniotic fluid. Affected individuals are asymptomatic and present normal development.

Alpha-fetoprotein, hereditary persistence: A benign autosomal dominant condition characterized by continued expression of alpha-fetoprotein in ***** life.
Sequence Similarities: Belongs to the ALB/AFP/VDB family.
Post-Translational Modification: Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.
Cellular Location: Secreted.
Database Links:
  • Entrez Gene: 174 Human
  • Omim: 104150 Human
  • SwissProt: P02771 Human
  • Unigene: 518808 Human
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    Synonyms:
  • Afp Antibody
  • AFPD Antibody
  • alpha 1 Fetoprotein Antibody
  • Alpha fetoglobulin Antibody
  • Alpha fetoprotein Antibody
  • Alpha fetoprotein precursor Antibody
  • Alpha-1-fetoprotein Antibody
  • Alpha-fetoglobulin Antibody
  • Alpha-fetoprotein Antibody
  • alpha-fetoprotein, Hereditary persistence of, included Antibody
  • FETA Antibody
  • FETA_HUMAN Antibody
  • Hereditary persistence of alpha fetoprotein Antibody
  • HPAFP Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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