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Anti-Cyclin E1 (I119) Antibody

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产品名称: Anti-Cyclin E1 (I119) Antibody
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Anti-Cyclin E1 (I119) Antibody


Anti-Cyclin E1 (I119) Antibody  的详细介绍
Name: Anti-Cyclin E1 (I119) Antibody
See all Cyclin E1 primary antibodies
Description: Rabbit polyclonal antibody to Cyclin E1 (I119)
Specificity: Cyclin E1 (I119) pAb detects endogenous levels of Cyclin E1 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 90-135 of Human Cyclin E1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 49 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Essential for the control of the cell cycle at the G1/S (start) transition.
Tissue Specificity: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
Sequence Similarities: Belongs to the cyclin family. Cyclin E subfamily.
Post-Translational Modification: Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 898?Human
  • Entrez Gene: 12447?Mouse
  • Entrez Gene: 25729?Rat
  • Omim: 123837?Human
  • SwissProt: P24864?Human
  • SwissProt: Q61457?Mouse
  • SwissProt: P39949?Rat
  • Unigene: 244723?Human
  • Unigene: 16110?Mouse
  • Unigene: 15455?Rat
    		•
    Synonyms:
  • CCNE Antibody
  • Ccne1 Antibody
  • CCNE1_HUMAN Antibody
  • cyclin E variant ex5del Antibody
  • cyclin E variant ex7del Antibody
  • Cyclin E1 Antibody
  • Cyclin Es Antibody
  • Cyclin Et Antibody
  • CyclinE Antibody
  • G1/S specific cyclin E Antibody
  • G1/S-specific cyclin-E1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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