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Anti-CHOP (K121) Antibody

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产品名称: Anti-CHOP (K121) Antibody
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Anti-CHOP (K121) Antibody


Anti-CHOP (K121) Antibody  的详细介绍
Name: Anti-CHOP (K121) Antibody
See all CHOP primary antibodies
Description: Rabbit polyclonal antibody to CHOP (K121)
Specificity: CHOP (K121) pAb detects endogenous levels of CHOP protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human CHOP.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 19,27 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP s in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
Involvement in Disease: Myxoid liposarcoma: A soft tissue tumor that tends to occur in the limbs (especially the thigh) of patients ranging in age from 35 to 55 years. It is defined by the presence of a hypocellular spindle cell proliferation set in a myxoid background, often with mucin pooling. Lipoblasts tend to be small and often monovacuolated and to cluster around vessels or at the periphery of the lesion.
Sequence Similarities: Belongs to the bZIP family.
Post-Translational Modification: Ubiquitinated, leading to its degradation by the proteasome.
Cellular Location: Cytoplasm. Nucleus.

Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation.
Database Links:
  • Entrez Gene: 1649?Human
  • Entrez Gene: 13198?Mouse
  • Entrez Gene: 29467?Rat
  • Omim: 126337?Human
  • SwissProt: P35638?Human
  • SwissProt: P35639?Mouse
  • SwissProt: Q62857?Rat
  • Unigene: 505777?Human
  • Unigene: 728989?Human
  • Unigene: 110220?Mouse
  • Unigene: 11183?Rat
    		•
    Synonyms:
  • C/EBP homologous protein Antibody
  • C/EBP Homology Protein Antibody
  • C/EBP zeta Antibody
  • C/EBP-homologous protein Antibody
  • C/EBP-homologous protein 10 Antibody
  • CCAAT/enhancer binding protein homologous protein Antibody
  • CEBPZ Antibody
  • CHOP Antibody
  • CHOP 10 Antibody
  • CHOP-10 Antibody
  • CHOP10 Antibody
  • DDIT 3 Antibody
  • DDIT-3 Antibody
  • DDIT3 Antibody
  • DDIT3_HUMAN Antibody
  • DNA Damage Inducible Transcript 3 Antibody
  • DNA damage-inducible transcript 3 protein Antibody
  • GADD 153 Antibody
  • GADD153 Antibody
  • Growth Arrest and DNA Damage Inducible Protein 153 Antibody
  • Growth arrest and DNA damage inducible protein GADD153 Antibody
  • Growth arrest and DNA damage-inducible protein GADD153 Antibody
  • MGC4154 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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