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Anti-CD8a Antibody

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产品名称: Anti-CD8a Antibody
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简单介绍

Anti-CD8a Antibody


Anti-CD8a Antibody  的详细介绍
Name: Anti-CD8a Antibody
See all CD8 alpha primary antibodies
Description: Rat monoclonal (53-6.7) antibody to CD8a.
Specificity: The rat monoclonal antibody 53-6.7 recognizes mouse CD8a (32-34 kDa; alpha chain of the CD8 antigen).
Applications: FC, IP, IHC-P, IHC-Fr, ICC, FUNC
Reactivity: Mouse
Immunogen: Mouse spleen cells.
Host: Rat
Clonality: Monoclonal
Clone: 53-6.7
Isotype: IgG2a
Conjugate: Unconjugated
Purification: Protein A chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage: Store at 2-8°C.
Function: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Post-Translational Modification: Palmitoylated, but association with CD8B seems to be more important for the enrichment of CdD8A in lipid rafts.
Cellular Location: Cell membrane.

Cd8a localizes to lipid rafts only when associated with its partner Cd8b.
Database Links:
  • Entrez Gene: 12525?Mouse
  • SwissProt: P01731?Mouse
  • Unigene: 1858?Mouse
    		•
    Synonyms:
  • alpha polypeptide (p32) Antibody
  • CD8 Antibody
  • CD8 alpha Antibody
  • CD8 antigen alpha polypeptide Antibody
  • CD8 antigen alpha polypeptide (p32) Antibody
  • CD8a Antibody
  • CD8A antigen Antibody
  • CD8A molecule Antibody
  • CD8A_HUMAN Antibody
  • Leu2 Antibody
  • Leu2 T lymphocyte antigen Antibody
  • Ly3 Antibody
  • LYT3 Antibody
  • MAL Antibody
  • OKT8 T cell antigen Antibody
  • OTTHUMP00000160760 Antibody
  • OTTHUMP00000160764 Antibody
  • OTTHUMP00000203528 Antibody
  • OTTHUMP00000203721 Antibody
  • p32 Antibody
  • T cell antigen Leu2 Antibody
  • T cell co receptor Antibody
  • T-cell surface glycoprotein CD8 alpha chain Antibody
  • T-lymphocyte differentiation antigen T8/Leu-2 Antibody
  • T8 T cell antigen Antibody
  • T8/Leu-2 T-lymphocyte differentiation antigen Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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