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Anti-Caspase 9 (Tyr153) Antibody

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产品名称: Anti-Caspase 9 (Tyr153) Antibody
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Anti-Caspase 9 (Tyr153) Antibody


Anti-Caspase 9 (Tyr153) Antibody  的详细介绍
Name: Anti-Caspase 9 (Tyr153) Antibody
See all Caspase 9 primary antibodies
Description: Rabbit polyclonal antibody to Caspase 9 (Tyr153)
Specificity: Caspase 9 (Tyr153) pAb detects endogenous levels of full length caspase-9 (48 kDa) and large fragments of caspase-9 (35 kDa).
Applications: WB
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 130-180 of Human Caspase 9.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 35,48 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
Tissue Specificity: Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
Sequence Similarities: Belongs to the peptidase C14A family.
Post-Translational Modification: Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.
Synonyms:
  • APAF3 Antibody
  • CASP9 Antibody
  • Caspase 9 Antibody
  • ICE LAP6 Antibody
  • MCH6 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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