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TNF a Human

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TNF a Human


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Name: TNF a Human
Description: Tumor Necrosis Factor-Alpha Human Recombinant
Source: Escherichia Coli.
Sequence: MVRSSSRTPS DKPVAHVVAN PQAEGQLQWL NRRANALLAN GVELRDNQLV VPSEGLYLIY SQVLFKGQGC PSTHVLLTHT ISRIAVSYQT KVNLLSAIKS PCQRETPEGA E AKPWYEPIY LGGVFQLEKG DRLSAEINRP DYLDFAESGQ VYFGIIAL.
Product Form: Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation: 1mg of TNF-alpha Human contain 20mM PB, pH-7.2, and 100mM NaCl.
Purity: Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Storage: Lyophilized Tumor Necrosis Factor-a although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TNF-a should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918).
Involvement in Disease: Psoriatic arthritis: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
Sequence Similarities: Belongs to the tumor necrosis factor family.
Post-Translational Modification: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
Cellular Location: Cell membrane.
UniProt: P01375
Synonyms:
  • APC1
  • APC1 protein
  • Cachectin
  • DIF
  • Differentiation inducing factor
  • Macrophage cytotoxic factor
  • soluble form
  • Tnf
  • TNF a
  • TNF alpha
  • TNF macrophage derived
  • TNF monocyte derived
  • TNF superfamily member 2
  • TNF superfamily, member 2
  • TNF, macrophage derived
  • TNF, monocyte derived
  • TNF-a
  • TNF-alpha
  • TNFA
  • TNFA_HUMAN
  • TNFSF2
  • Tumor necrosis factor
  • Tumor necrosis factor (TNF superfamily member 2)
  • Tumor necrosis factor alpha
  • Tumor necrosis factor ligand superfamily member 2
  • Tumor Necrosis Factor, Membrane Form
  • Tumor necrosis factor, soluble form
    		•
    Information: Protein information shown above is from the UniProt Consortium.
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