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Anti-HIST3H3 Antibody

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产品名称: Anti-HIST3H3 Antibody
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Anti-HIST3H3 Antibody


Anti-HIST3H3 Antibody  的详细介绍
Name: Anti-HIST3H3 Antibody
See all HIST3H3 primary antibodies
Description: Rabbit polyclonal antibody to HIST3H3.
Applications: WB, IHC, ChIP
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, ChIP: 1:20 - 1:100.
Immunogen: A synthetic peptide of human HIST3H3.
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Tissue Specificity: Expressed in testicular cells.
Sequence Similarities: Belongs to the histone H3 family.
Post-Translational Modification: Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
Cellular Location: Nucleus. Chromosome.
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