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Antibodies
Anti-HIST3H3 Antibody
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产品名称:
Anti-HIST3H3 Antibody
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简单介绍
Anti-HIST3H3
Antibody
Anti-HIST3H3 Antibody
的详细介绍
Overview
Name:
Anti-HIST3H3
Antibody
See all HIST3H3 primary antibodies
Description:
Rabbit polyclonal antibody to HIST3H3.
Applications:
WB, IHC, IF, IP, ChIP
Dilutions:
WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200, IP: 1:50 - 1:200, ChIP: 1:50 - 1:200.
Reactivity:
Human, Mouse, Rat
Immunogen:
A synthetic peptide of human HIST3H3.
Host:
Rabbit
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Unconjugated
Purification:
Affinity purification.
Product Form:
Liquid
Formulation:
Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Target
Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Tissue Specificity:
Expressed in testicular cells.
Sequence Similarities:
Belongs to the histone H3 family.
Post-Translational Modification:
Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
Cellular Location:
Nucleus. Chromosome.
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