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Anti-CD11a Antibody

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Anti-CD11a Antibody


Anti-CD11a Antibody  的详细介绍
Name: Anti-CD11a Antibody
See all CD11a primary antibodies
Description: Mouse monoclonal (MEM-25) antibody to CD11a.
Specificity: The antibody MEM-25 reacts with CD11a (alpha subunit of human LFA-1), a 170-180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.
Applications: FC, IP, FUNC
Reactivity: Human
Immunogen: Leukocytes from a patient suffering from a LGL Type leukemia.
Host: Mouse
Clonality: Monoclonal
Clone: MEM-25
Isotype: IgG1
Conjugate: Unconjugated
Purification: Protein A chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage: Store at 2-8°C.
Function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Tissue Specificity: Leukocytes.
Sequence Similarities: Belongs to the integrin alpha chain family.
Post-Translational Modification: In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.
Cellular Location: Cell membrane.
Database Links:
  • Entrez Gene: 3683 Human
  • Omim: 153370 Human
  • SwissProt: P20701 Human
  • Unigene: 174103 Human
    		•
    Synonyms:
  • Lymphocyte function associated antigen, type 1, alpha subunit Antibody
  • Antigen CD11A Antibody
  • Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide Antibody
  • CD 11a Antibody
  • CD11 antigen-like family member A Antibody
  • CD11a Antibody
  • CD11a antigen Antibody
  • Integrin Alpha L Antibody
  • Integrin alpha-L Antibody
  • Integrin gene promoter Antibody
  • Integrin, alpha L (antigen CD11A (p180), lymphocyte function associated antigen 1; alpha polypeptide) Antibody
  • ITAL_HUMAN Antibody
  • Itgal Antibody
  • ITGAL protein Antibody
  • Leukocyte adhesion glycoprotein LFA 1 alpha chain Antibody
  • Leukocyte adhesion glycoprotein LFA-1 alpha chain Antibody
  • Leukocyte Adhesion Glycoprotein LFA1 Alpha Chain Antibody
  • Leukocyte function associated molecule 1 alpha chain Antibody
  • Leukocyte function-associated molecule 1 alpha chain Antibody
  • LFA 1 Antibody
  • LFA 1 alpha Antibody
  • LFA 1 alpha (LFA1A) Antibody
  • LFA 1A Antibody
  • LFA-1A Antibody
  • LFA1A Antibody
  • Ly15 Antibody
  • Ly21 Antibody
  • Lymphocyte function associated antigen 1 Antibody
  • Lymphocyte Function Associated Antigen Type 1 alpha Antibody
  • lymphocyte function-associated antigen 1, alpha polypeptide Antibody
  • p180 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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