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Anti-TLR4 (S441) Antibody

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产品名称: Anti-TLR4 (S441) Antibody
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Anti-TLR4 (S441) Antibody


Anti-TLR4 (S441) Antibody  的详细介绍
Name: Anti-TLR4 (S441) Antibody
See all TLR4 primary antibodies
Description: Rabbit polyclonal antibody to TLR4 (S441)
Specificity: TLR4 (S441) pAb detects endogenous levels of TLR4 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 421-470 of Human TLR4.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 100 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific (PubMed:20711192). Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression (PubMed:15809303). In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via TLR2, but also partially via this receptor (PubMed:16622205).
Tissue Specificity: Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells.
Sequence Similarities: Belongs to the Toll-like receptor family.
Post-Translational Modification: N-glycosylated. Glycosylation of Asn-526 and Asn-575 seems to be necessary for the expression of TLR4 on the cell surface and the LPS-response. Likewise, mutants lacking two or more of the other N-glycosylation sites were deficient in interaction with LPS.
Cellular Location: Cell membrane.

Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis.
Database Links:
  • Entrez Gene: 7099?Human
  • Entrez Gene: 21898?Mouse
  • Entrez Gene: 29260?Rat
  • Omim: 603030?Human
  • SwissProt: O00206?Human
  • SwissProt: Q9QUK6?Mouse
  • SwissProt: Q9QX05?Rat
  • Unigene: 174312?Human
  • Unigene: 38049?Mouse
  • Unigene: 14534?Rat
    		•
    Synonyms:
  • ARMD10 Antibody
  • CD284 Antibody
  • CD284 antigen Antibody
  • Homolog of Drosophila toll Antibody
  • hToll Antibody
  • TLR 4 Antibody
  • TLR4 Antibody
  • TLR4_HUMAN Antibody
  • TOLL Antibody
  • Toll like receptor 4 Antibody
  • Toll-like receptor 4 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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