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Anti-VEGF-A Antibody

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产品名称: Anti-VEGF-A Antibody
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Anti-VEGF-A Antibody


Anti-VEGF-A Antibody  的详细介绍
Name: Anti-VEGF-A Antibody
See all VEGFA primary antibodies
Description: Rabbit polyclonal antibody to VEGF-A
Specificity: VEGFA pAb detects endogenous levels of VEGFA protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human VEGF-A.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 27 kDa (VEGF206); 45 kDa (L-VEGF206); ~ 15-44 kDa (Others Isoform)
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
Tissue Specificity: Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland.
Involvement in Disease: Microvascular complications of diabetes 1: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic *****s. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Sequence Similarities: Belongs to the PDGF/VEGF growth factor family.
Cellular Location: Secreted.

VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
Database Links:
  • Entrez Gene: 7422?Human
  • Entrez Gene: 22339?Mouse
  • Entrez Gene: 83785?Rat
  • Omim: 192240?Human
  • SwissProt: P15692?Human
  • SwissProt: Q00731?Mouse
  • SwissProt: P16612?Rat
  • Unigene: 73793?Human
  • Unigene: 282184?Mouse
  • Unigene: 1923?Rat
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    Synonyms:
  • Folliculostellate cell-derived growth factor Antibody
  • Glioma-derived endothelial cell mitogen Antibody
  • MGC70609 Antibody
  • MVCD1 Antibody
  • vascular endothelial growth factor Antibody
  • Vascular endothelial growth factor A Antibody
  • vascular endothelial growth factor A121 Antibody
  • vascular endothelial growth factor A165 Antibody
  • Vascular permeability factor Antibody
  • Vegf Antibody
  • VEGF A Antibody
  • VEGF-A Antibody
  • VEGF120 Antibody
  • VEGFA Antibody
  • VEGFA_HUMAN Antibody
  • VPF Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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