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Anti-Syk Antibody

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Anti-Syk Antibody


Anti-Syk Antibody  的详细介绍
Name: Anti-Syk Antibody
See all Syk primary antibodies
Description: Mouse monoclonal (SYK-01) antibody to Syk.
Specificity: The antibody SYK-01 reacts with protein tyrosine kinase p72Syk (Syk; Syk family tyrosine-specific phospho-transferase), which is required for the transduction of signals through the B cell antigen receptor (BCR) and the high affinity IgE receptor (FcepsilonRI).
Applications: IP, WB, IHC-P, ICC
Reactivity: Mouse, Human, Rat
Immunogen: Recombinant fragment (aa 5-360) of human Syk.
Host: Mouse
Clonality: Monoclonal
Clone: SYK-01
Isotype: IgG1
Conjugate: Unconjugated
Purification: Protein A chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage: Store at 2-8°C.
Function: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity).
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
Post-Translational Modification: Autophosphorylated. Phosphorylated on tyrosine residues by LYN following receptors engagement. Phosphorylation on Tyr-317 creates a for CBL, an adapter protein that serves as a negative regulator of BCR-stimulated calcium ion signaling (By similarity). Phosphorylation at Tyr-342 creates a for VAV1 (By similarity). Phosphorylation on Tyr-342 and Tyr-346 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of calcium ion mobilization via a phosphoinositide 3-kinase-independent pathway (By similarity). Phosphorylation on Ser-291 is very common, it peaks 5 minutes after BCR stimulation, and creates a for YWHAG (By similarity). Phosphorylation at Tyr-624 creates a for BLNK (By similarity). Dephosphorylated by PTPN6 (By similarity).
Cellular Location: Cell membrane. Cytoplasm > Cytosol.
Database Links:
  • Entrez Gene: 6850?Human
  • Entrez Gene: 20963?Mouse
  • Entrez Gene: 25155?Rat
  • Omim: 600085?Human
  • SwissProt: P43405?Human
  • SwissProt: P48025?Mouse
  • SwissProt: Q64725?Rat
  • Unigene: 371720?Human
  • Unigene: 375031?Mouse
  • Unigene: 87407?Rat
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    Synonyms:
  • EC 2.7.10.2 Antibody
  • kinase Syk Antibody
  • KSYK Antibody
  • KSYK_HUMAN Antibody
  • p72-Syk Antibody
  • p72syk Antibody
  • Spleen tyrosine kinase Antibody
  • Syk Antibody
  • Tyrosine protein kinase SYK Antibody
  • Tyrosine-protein kinase SYK Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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