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Anti-CD59 Antibody

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产品名称: Anti-CD59 Antibody
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Anti-CD59 Antibody


Anti-CD59 Antibody  的详细介绍
Name: Anti-CD59 Antibody
See all CD59 primary antibodies
Description: Mouse monoclonal (MEM-43) antibody to CD59.
Specificity: The antibody MEM-43 reacts with well defined epitope (W40, R-53) on CD59 (Protectin), an 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on all hematopoietic cells; it is widely present on cells in all tissues.
Applications: FC, IP, IHC-P
Reactivity: Human
Immunogen: Thymocytes and T lymphocytes.
Host: Mouse
Clonality: Monoclonal
Clone: MEM-43
Isotype: IgG2a
Conjugate: Unconjugated
Purification: Protein A chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage: Store at 2-8°C.
Function: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
Involvement in Disease: Hemolytic anemia, CD59-mediated, with or without polyneuropathy: An autosomal recessive disorder characterized by infantile onset of chronic hemolysis and a relapsing-remitting polyneuropathy, often exacerbated by infection, and manifested as hypotonia, limb muscle weakness, and hyporeflexia.
Post-Translational Modification: N- and O-glycosylated. The N-glycosylation mainly consists of a family of biantennary complex-type structures with and without lactosamine extensions and outer arm fucose residues. Also significant amounts of triantennary complexes (22%). Variable sialylation also present in the Asn-43 oligosaccharide. The predominant O-glycans are mono-sialylated forms of the disaccharide, Gal-beta-1,3GalNAc, and their sites of attachment are probably on Thr-76 and Thr-77. The GPI-anchor of soluble urinary CD59 has no inositol-associated phospholipid, but is composed of seven different GPI-anchor variants of one or more monosaccharide units. Major variants contain sialic acid, mannose and glucosamine. Sialic acid linked to an N-acetylhexosamine-galactose arm is present in two variants.
Cellular Location: Cell membrane. Secreted.

Soluble form found in a number of tissues.
Database Links:
  • Entrez Gene: 966?Human
  • Omim: 107271?Human
  • SwissProt: P13987?Human
  • Unigene: 278573?Human
  • Unigene: 709466?Human
  • Unigene: 710641?Human
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    Synonyms:
  • 16.3A5 Antibody
  • 1F5 Antibody
  • 1F5 antigen Antibody
  • 20 kDa homologous restriction factor Antibody
  • CD 59 Antibody
  • CD59 Antibody
  • CD59 antigen Antibody
  • CD59 antigen complement regulatory protein Antibody
  • CD59 antigen p18 20 Antibody
  • CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) Antibody
  • CD59 glycoprotein Antibody
  • CD59 molecule Antibody
  • CD59 molecule complement regulatory protein Antibody
  • Cd59a Antibody
  • CD59_HUMAN Antibody
  • CD_antigen=CD59 Antibody
  • Complement regulatory protein Antibody
  • EJ16 Antibody
  • EJ30 Antibody
  • EL32 Antibody
  • FLJ38134 Antibody
  • FLJ92039 Antibody
  • G344 Antibody
  • HRF 20 Antibody
  • HRF-20 Antibody
  • HRF20 Antibody
  • Human leukocyte antigen MIC11 Antibody
  • Ly 6 like protein Antibody
  • Lymphocytic antigen CD59/MEM43 Antibody
  • MAC inhibitory protein Antibody
  • MAC IP Antibody
  • MAC-inhibitory protein Antibody
  • MAC-IP Antibody
  • MACIF Antibody
  • MACIP Antibody
  • MEM43 Antibody
  • MEM43 antigen Antibody
  • Membrane attack complex (MAC) inhibition factor Antibody
  • Membrane attack complex inhibition factor Antibody
  • Membrane inhibitor of reactive lysis Antibody
  • MGC2354 Antibody
  • MIC11 Antibody
  • MIN1 Antibody
  • MIN2 Antibody
  • MIN3 Antibody
  • MIRL Antibody
  • MSK21 Antibody
  • p18 20 Antibody
  • Protectin Antibody
  • Surface antigen recognized by monoclonal Antibody
  • T cell activating protein Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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