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Anti-Bax (S163) Antibody

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产品名称: Anti-Bax (S163) Antibody
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Anti-Bax (S163) Antibody


Anti-Bax (S163) Antibody  的详细介绍
Name: Anti-Bax (S163) Antibody
See all Bax primary antibodies
Description: Rabbit polyclonal antibody to Bax (S163)
Specificity: Bax (S163) pAb detects endogenous levels of Bax protein.
Applications: WB, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 150-200 of Human Bax.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 21 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Tissue Specificity: Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.
Sequence Similarities: Belongs to the Bcl-2 family.
Cellular Location: Mitochondrion membrane. Cytoplasm.

Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane.
Database Links:
  • Entrez Gene: 581 Human
  • Entrez Gene: 12028 Mouse
  • Entrez Gene: 24887 Rat
  • Omim: 600040 Human
  • SwissProt: Q07812 Human
  • SwissProt: Q07813 Mouse
  • SwissProt: Q63690 Rat
  • Unigene: 624291 Human
  • Unigene: 19904 Mouse
  • Unigene: 10668 Rat
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    Synonyms:
  • Apoptosis regulator BAX Antibody
  • Bax Antibody
  • Bax-protein Antibody
  • BAXA Antibody
  • Baxdelta2G9 Antibody
  • Baxdelta2G9omega Antibody
  • Baxdelta2omega Antibody
  • BAX_HUMAN Antibody
  • Bcl-2-like protein 4 Antibody
  • BCL2 associated X protein Antibody
  • BCL2 associated X protein omega Antibody
  • BCL2 associated X protein transcript variant delta2 Antibody
  • Bcl2-L-4 Antibody
  • BCL2L4 Antibody
  • membrane isoform alpha Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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