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Antibodies
Anti-CD146 Antibody
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产品名称:
Anti-CD146 Antibody
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简单介绍
Anti-CD146
Antibody
Anti-CD146 Antibody
的详细介绍
Overview
Name:
Anti-CD146
Antibody
See all CD146 primary antibodies
Description:
Mouse monoclonal (P1H12) antibody to CD146.
Specificity:
The mouse monoclonal antibody P1H12 recognizes CD146, a 118 kDa transmembrane glycoprotein expressed on epithelial and endothelial cells, fibroblasts, multipotent mesenchymal stromal cells, melanoma cells, activated T cells and activated keratinocytes.
Applications:
FC, IP, WB, IHC-P, IHC-Fr, ICC
Reactivity:
Human, Mouse, Dog, Rabbit
Immunogen:
Cultured human umbilical cells.
Host:
Mouse
Clonality:
Monoclonal
Clone:
P1H12
Isotype:
IgG1
Conjugate:
Unconjugated
Purification:
Protein A chromatography.
Concentration:
1 mg/ml
Purity:
> 95% (by SDS-PAGE)
Product Form:
Liquid
Formulation:
Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage:
Store at 2-8°C.
Target
Function:
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity).
Tissue Specificity:
Detected in melanoma cell lines.
Cellular Location:
Membrane.
Database Links:
Entrez Gene: 4162?Human
Entrez Gene: 84004?Mouse
Omim: 155735?Human
SwissProt: P43121?Human
SwissProt: Q8R2Y2?Mouse
Unigene: 599039?Human
Unigene: 275003?Mouse
Synonyms:
A32 antigen Antibody
CD 146 Antibody
CD146 Antibody
CD146 antigen Antibody
Cell surface glycoprotein MUC18 Antibody
Cell surface glycoprotein P1H12 Antibody
Gicerin Antibody
Mcam Antibody
Melanoma adhesion molecule Antibody
Melanoma associated antigen A32 Antibody
Melanoma associated antigen MUC18 Antibody
Melanoma associated glycoprotein MUC18 Antibody
Melanoma cell adhesion molecule Antibody
Melanoma-associated antigen A32 Antibody
Melanoma-associated antigen MUC18 Antibody
MelCAM Antibody
MUC 18 Antibody
MUC18 Antibody
MUC18_HUMAN Antibody
S endo 1 Antibody
S endo 1 endothelial associated antigen Antibody
S-endo 1 endothelial-associated antigen Antibody
Information:
Target information shown above is from the UniProt Consortium.
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