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Antibodies
Anti-p63 Protein Antibody
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产品名称:
Anti-p63 Protein Antibody
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简单介绍
Anti-p63 Protein
Antibody
Anti-p63 Protein Antibody
的详细介绍
Overview
Name:
Anti-p63 Protein
Antibody
See all p63 primary antibodies
Description:
Mouse monoclonal (4A4) antibody to p63 Protein.
Specificity:
p63 protein (nuclear), 6 Isotypes.
Applications:
IHC
Reactivity:
Human, Mouse, Rat?
Immunogen:
Recombinant human p63 protein (aa 1-205).
Host:
Mouse
Clonality:
Monoclonal
Clone:
4A4
Isotype:
IgG2a
Conjugate:
Unconjugated
Product Form:
Liquid
Formulation:
Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Storage:
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes:
p63 is known as an excellent marker of basal cells in squamous epithelia and transitional cell epithelia (localisation of the antigen in cell nuclei) . It is well suited for the detection of squamous cell carcinoma. In prostate tissue 80% of basal cells in benign tissue react positive, whereas p63 disappears in prostate carcinoma.
Target
Function:
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates RIPK4 transcription (By similarity). Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter (By similarity).
Tissue Specificity:
Widely expressed, notably in thymus, prostate, placenta, and skeletal muscle, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast and prostate express high levels of DeltaN-type isoforms.
Sequence Similarities:
Belongs to the p53 family.
Post-Translational Modification:
May be sumoylated.
Cellular Location:
Nucleus.
Database Links:
Entrez Gene: 8626?Human
Entrez Gene: 22061?Mouse
Entrez Gene: 246334?Rat
Omim: 603273?Human
SwissProt: Q9H3D4?Human
SwissProt: O88898?Mouse
SwissProt: Q9JJP6?Rat
Unigene: 137569?Human
Unigene: 20894?Mouse
Unigene: 42907?Rat
Synonyms:
AIS Antibody
Amplified in squamous cell carcinoma Antibody
B(p51A) Antibody
B(p51B) Antibody
Chronic ulcerative stomatitis protein Antibody
CUSP Antibody
DN p63 alpha 1 Antibody
DNp63 Antibody
EEC3 Antibody
id:ibd3516 Antibody
Keratinocyte transcription factor Antibody
Keratinocyte transcription factor KET Antibody
KET Antibody
LMS Antibody
MGC115972 Antibody
MGC192897 Antibody
NBP Antibody
OFC8 Antibody
OTTHUMP00000209732 Antibody
OTTHUMP00000209733 Antibody
OTTHUMP00000209734 Antibody
OTTHUMP00000209735 Antibody
OTTHUMP00000209737 Antibody
OTTHUMP00000209738 Antibody
OTTHUMP00000209739 Antibody
OTTHUMP00000209740 Antibody
OTTHUMP00000209741 Antibody
OTTHUMP00000209742 Antibody
OTTHUMP00000209743 Antibody
OTTHUMP00000209744 Antibody
p40 Antibody
p51 Antibody
P51/P63 Antibody
p53-related protein p63 Antibody
p53CP Antibody
p63 Antibody
P63_HUMAN Antibody
p73H Antibody
p73L Antibody
RHS Antibody
SHFM4 Antibody
TAp63alpha Antibody
TP53CP Antibody
TP53L Antibody
TP63 Antibody
TP73L Antibody
Transformation related protein 63 Antibody
Transformation-related protein 63 Antibody
Trp53rp1 Antibody
Trp63 Antibody
Tumor protein 63 Antibody
Tumor protein p53-competing protein Antibody
Tumor protein p53-like Antibody
Tumor protein p63 Antibody
Tumor protein p63 deltaN isoform delta Antibody
Tumor protein p73 Antibody
Tumor protein p73-like Antibody
Information:
Target information shown above is from the UniProt Consortium.
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