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Anti-Nrf2 (L593) Antibody

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产品名称: Anti-Nrf2 (L593) Antibody
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Anti-Nrf2 (L593) Antibody


Anti-Nrf2 (L593) Antibody  的详细介绍
Name: Anti-Nrf2 (L593) Antibody
See all Nrf2 primary antibodies
Description: Rabbit polyclonal antibody to Nrf2 (L593)
Specificity: Nrf2/NFE2L2 (L593) pAb detects endogenous levels of Nrf2/NFE2L2 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 560-621 of Human Nrf2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 68 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Tissue Specificity: Widely expressed. Highest expression in ***** muscle, kidney, lung, liver and in fetal muscle.
Sequence Similarities: Belongs to the bZIP family. CNC subfamily.
Post-Translational Modification: Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.
Cellular Location: Cytoplasm > Cytosol. Nucleus.

Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
Database Links:
  • Entrez Gene: 4780?Human
  • Entrez Gene: 18024?Mouse
  • Entrez Gene: 83619?Rat
  • Omim: 600492?Human
  • SwissProt: Q16236?Human
  • SwissProt: Q60795?Mouse
  • SwissProt: O54968?Rat
  • Unigene: 744006?Human
  • Unigene: 1025?Mouse
  • Unigene: 10867?Rat
    		•
    Synonyms:
  • erythroid derived 2 Antibody
  • HEBP1 Antibody
  • like 2 Antibody
  • NF E2 related factor 2 Antibody
  • NF-E2-related factor 2 Antibody
  • NF2L2_HUMAN Antibody
  • NFE2 related factor 2 Antibody
  • NFE2-related factor 2 Antibody
  • Nfe2l2 Antibody
  • Nrf 2 Antibody
  • Nrf2 Antibody
  • Nuclear factor Antibody
  • Nuclear factor (erythroid derived 2) like 2 Antibody
  • nuclear factor erythroid 2 like 2 Antibody
  • Nuclear factor erythroid 2 related factor 2 Antibody
  • Nuclear factor erythroid 2-related factor 2 Antibody
  • Nuclear factor erythroid derived 2 like 2 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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