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Anti-PCNA (I88) Antibody

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产品名称: Anti-PCNA (I88) Antibody
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Anti-PCNA (I88) Antibody


Anti-PCNA (I88) Antibody  的详细介绍
Name: Anti-PCNA (I88) Antibody
See all PCNA primary antibodies
Description: Rabbit polyclonal antibody to PCNA (I88)
Specificity: PCNA (I88) pAb detects endogenous levels of PCNA protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 51-100 of Human PCNA.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 29, 36 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
Involvement in Disease: Ataxia-telangiectasia-like disorder 2: A neurodegenerative disorder due to defects in DNA excision repair. ATLD2 is characterized by developmental delay, ataxia, sensorineural hearing loss, short stature, cutaneous and ocular telangiectasia, and photosensitivity.
Sequence Similarities: Belongs to the PCNA family.
Post-Translational Modification: Phosphorylated. Phosphorylation at Tyr-211 by EGFR stabilizes chromatin-associated PCNA.
Cellular Location: Nucleus.

Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
Database Links:
  • Entrez Gene: 5111?Human
  • Entrez Gene: 18538?Mouse
  • Entrez Gene: 25737?Rat
  • Omim: 176740?Human
  • SwissProt: P12004?Human
  • SwissProt: P17918?Mouse
  • SwissProt: P04961?Rat
  • Unigene: 147433?Human
  • Unigene: 728886?Human
  • Unigene: 7141?Mouse
  • Unigene: 223?Rat
    		•
    Synonyms:
  • ATLD2 Antibody
  • cb16 Antibody
  • Cyclin Antibody
  • DNA polymerase delta auxiliary protein Antibody
  • etID36690.10 Antibody
  • fa28e03 Antibody
  • fb36g03 Antibody
  • HGCN8729 Antibody
  • MGC8367 Antibody
  • Mutagen-sensitive 209 protein Antibody
  • OTTHUMP00000030189 Antibody
  • OTTHUMP00000030190 Antibody
  • PCNA Antibody
  • Pcna/cyclin Antibody
  • PCNAR Antibody
  • PCNA_HUMAN Antibody
  • Polymerase delta accessory protein Antibody
  • Proliferating cell nuclear antigen Antibody
  • wu:fa28e03 Antibody
  • wu:fb36g03 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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