产品资料

Anti-PIM2 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-PIM2 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-PIM2 Antibody


Anti-PIM2 Antibody  的详细介绍
Name: Anti-PIM2 Antibody
See all PIM2 primary antibodies
Description: Goat polyclonal antibody to PIM2.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human PIM2 (internal region).
Sequence: C-PPGGKDREAFEAE
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
Tissue Specificity: Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in hepatocellular carcinoma tissues.
Sequence Similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
Post-Translational Modification: Autophosphorylated.
Database Links:
  • Entrez Gene: 11040 Human
  • Omim: 300295 Human
  • SwissProt: Q9P1W9 Human
  • Unigene: 726382 Human
    		•
    Synonyms:
  • OTTHUMP00000025825 Antibody
  • Pim 2 oncogene Antibody
  • Pim 2h Antibody
  • Pim-2h Antibody
  • PIM2 Antibody
  • PIM2 Oncogene Antibody
  • Pim2h Antibody
  • PIM2_HUMAN Antibody
  • Proto Oncogene PIM2 Antibody
  • Proto-oncogene Pim-2 (serine threonine kinase) Antibody
  • Serine/threonine kinase PIM2 Antibody
  • Serine/threonine-protein kinase Pim-2 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号