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Anti-Cox-2 (T594) Antibody

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产品名称: Anti-Cox-2 (T594) Antibody
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Anti-Cox-2 (T594) Antibody


Anti-Cox-2 (T594) Antibody  的详细介绍
Name: Anti-Cox-2 (T594) Antibody
See all Cox2 primary antibodies
Description: Rabbit polyclonal antibody to Cox-2 (T594)
Specificity: Cox2 (T594) pAb detects endogenous levels of Cox2 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids C-terminus of Human Cox-2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 74 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
Sequence Similarities: Belongs to the prostaglandin G/H synthase family.
Post-Translational Modification: S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-526.
Cellular Location: Microsome membrane. Endoplasmic reticulum membrane.
Database Links:
  • Entrez Gene: 5743?Human
  • Entrez Gene: 19225?Mouse
  • Omim: 600262?Human
  • SwissProt: P35354?Human
  • SwissProt: Q05769?Mouse
  • Unigene: 196384?Human
  • Unigene: 292547?Mouse
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    Synonyms:
  • COX 2 Antibody
  • COX-2 Antibody
  • COX2 Antibody
  • Cyclooxygenase 2 Antibody
  • Cyclooxygenase 2b Antibody
  • Cyclooxygenase-2 Antibody
  • Glucocorticoid-regulated inframmatory prostagandin G/H synthase Antibody
  • GRIPGHS Antibody
  • hCox 2 Antibody
  • PGG/HS Antibody
  • PGH synthase 2 Antibody
  • PGH2_HUMAN Antibody
  • PGHS 2 Antibody
  • PGHS-2 Antibody
  • PGHS2 Antibody
  • PHS 2 Antibody
  • PHS II Antibody
  • Prostaglandin endoperoxide synthase 2 Antibody
  • Prostaglandin endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Antibody
  • Prostaglandin G/H synthase 2 Antibody
  • Prostaglandin G/H synthase and cyclooxygenase Antibody
  • Prostaglandin H2 synthase 2 Antibody
  • Prostaglandin-endoperoxide synthase 2 Antibody
  • PTGS2 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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