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Anti-IkB-α (phospho-S32/S36) Antibody

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产品名称: Anti-IkB-α (phospho-S32/S36) Antibody
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Anti-IkB-α (phospho-S32/S36) Antibody


Anti-IkB-α (phospho-S32/S36) Antibody  的详细介绍
Name: Anti-IkB-α (phospho-S32/S36) Antibody
See all IkB-α primary antibodies
Description: Rabbit polyclonal antibody to IkB-α (phospho-S32/S36)
Specificity: p-IκB-α (S32+S36) pAb detects endogenous levels of IκB-α protein only when phosphorylated at Ser32+S36.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic phosphopeptide derived from human IkB-α around the phosphorylation site of Serine 32/36.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 36 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Involvement in Disease: Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency autosomal dominant: A form of ectoderma dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. This form of ectodermal dysplasia is associated with decreased production of pro-inflammatory cytokines and certain interferons, rendering patients susceptible to infection.
Sequence Similarities: Belongs to the NF-kappa-B inhibitor family.
Post-Translational Modification: Phosphorylated; disables inhibition of NF-kappa-B DNA-binding activity. Phosphorylation at positions 32 and 36 is prerequisite to recognition by UBE2D3 leading to polyubiquitination and subsequent degradation.
Cellular Location: Cytoplasm. Nucleus.

Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
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