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Anti-PARK7 Antibody

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产品名称: Anti-PARK7 Antibody
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简单介绍

Anti-PARK7 Antibody


Anti-PARK7 Antibody  的详细介绍
Name: Anti-PARK7 Antibody
See all PARK7 primary antibodies
Description: Goat polyclonal antibody to PARK7.
Applications: ELISA, WB, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide corresponding to Human PARK7 (C terminal).
Sequence: C-AAQVKAPLVLKD
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity. Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function. It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (By similarity). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (By similarity). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity).
Tissue Specificity: Ubiquitous. Detected on epididymal sperm. Highly expressed in testis and prostate. Detected at lower levels in heart, lung, brain, liver, kidney, seminal vesicle, caput and corpus epididymis.
Sequence Similarities: Belongs to the peptidase C56 family.
Post-Translational Modification: Sumoylated on Lys-130 by PIAS2 or PIAS4; which is essential for cell-growth promoting activity and transforming activity.
Cellular Location: Cell membrane. Cytoplasm. Membrane raft. Nucleus. Mitochondrion.

Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (By similarity). Membrane raft localization in astrocytes and neuronal cells requires palmitoylation (PubMed:23847046).
Database Links:
  • Entrez Gene: 11315 Human
  • Entrez Gene: 57320 Mouse
  • Entrez Gene: 117287 Rat
  • Omim: 602533 Human
  • SwissProt: Q99497 Human
  • SwissProt: Q99LX0 Mouse
  • SwissProt: O88767 Rat
  • Unigene: 419640 Human
  • Unigene: 277349 Mouse
  • Unigene: 30105 Rat
    		•
    Synonyms:
  • CAP1 Antibody
  • DJ-1 Antibody
  • DJ1 Antibody
  • DJ1 protein Antibody
  • Epididymis secretory sperm binding protein Li 67p Antibody
  • FLJ27376 Antibody
  • FLJ34360 Antibody
  • FLJ92274 Antibody
  • HEL S 67p Antibody
  • Oncogene DJ1 Antibody
  • OTTHUMP00000001348 Antibody
  • OTTHUMP00000001349 Antibody
  • OTTHUMP00000001350 Antibody
  • OTTHUMP00000001351 Antibody
  • PARK7 Antibody
  • PARK7/DJ1 Antibody
  • PARK7_HUMAN Antibody
  • Parkinson disease (autosomal recessive, early onset) 7 Antibody
  • Parkinson disease protein 7 Antibody
  • Parkinson protein 7 Antibody
  • Protein DJ-1 Antibody
  • SP22 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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