首页
品牌
ELISA试剂盒
抗体抗原
公司新闻
技术文章
关于拜力
留言询价
产品资料
首页
>>>
产品目录
>>>
中国授权代理品牌
>>> 
Antibodies
Anti-KCNJ11 Antibody
点击看大图
如果您对该产品感兴趣的话,可以
产品名称:
Anti-KCNJ11 Antibody
产品型号:
产品展商:
其它品牌
产品文档:
无相关文档
简单介绍
Anti-KCNJ11
Antibody
Anti-KCNJ11 Antibody
的详细介绍
Overview
Name:
Anti-KCNJ11
Antibody
See all KCNJ11 primary antibodies
Description:
Goat polyclonal antibody to KCNJ11.
Applications:
ELISA, WB, IHC
Reactivity:
Human
Immunogen:
Synthetic peptide corresponding to Human KCNJ11 (internal region).
Sequence:
C-AEDPAKPRYRARQ
Host:
Goat
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Unconjugated
Purification:
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:
100 μg at 0.5 mg/ml.
Product Form:
Liquid
Formulation:
Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Target
Function:
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
Involvement in Disease:
Familial hyperinsulinemic hypoglycemia 2: Most common cause of persistent hypoglycemia in infancy. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur.
Diabetes mellitus, permanent neonatal: A rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
Transient neonatal diabetes mellitus 3: Neonatal diabetes mellitus, defined as insulin-requiring hyperglycemia within the first month of life, is a rare entity. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. In a significant number of patients with transient neonatal diabetes mellitus, diabetes type 2 appears later in life. The onset and severity of TNDM3 is variable with childhood-onset diabetes, gestational diabetes or *****-onset diabetes described.
Maturity-onset diabetes of the young 13: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early *****hood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
Sequence Similarities:
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
Post-Translational Modification:
Phosphorylation by MAPK1 results in changes in channel gating that destabilize the closed states and reduce the ATP sensitivity.
Cellular Location:
Membrane.
Database Links:
Entrez Gene: 3767?Human
Omim: 600937?Human
SwissProt: Q14654?Human
Unigene: 248141?Human
Synonyms:
ATP sensitive inward rectifier potassium channel 11 Antibody
Beta cell inward rectifier subunit Antibody
BIR Antibody
HHF 2 Antibody
HHF2 Antibody
IKATP Antibody
Inward rectifier K(+) channel Kir6.2 Antibody
Inwardly rectifying potassium channel KIR6.2 Antibody
IRK 11 Antibody
IRK11 Antibody
KCNJ11 Antibody
Kir 6.2 Antibody
Kir6.2 Antibody
MGC133230 Antibody
PHHI Antibody
Potassium channel inwardly rectifing subfamily J member 11 Antibody
Potassium channel, inwardly rectifying subfamily J member 11 Antibody
Potassium inwardly rectifying channel J11 Antibody
TNDM 3 Antibody
TNDM3 Antibody
Information:
Target information shown above is from the UniProt Consortium.
产品留言
标题
联系人
联系电话
内容
验证码
点击换一张
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!
相关产品
Anti-Fer Antibody
Anti-FER (Phospho-Tyr402) Antibody
Anti-FEN1 Antibody
Anti-FEN1 Antibody
Anti-FEN1 (A119) Antibody
Anti-FEN1 (7H8) Antibody
Anti-FEN-1 Antibody
Anti-FEM1B Antibody
Anti-FEM1A Antibody
Anti-FEM1A Antibody
Anti-FDXR Antibody
Anti-FDPS Antibody
Anti-FDPS Antibody
Anti-FDFT1 Antibody
Anti-FDFT1 Antibody
Anti-FDCSP Antibody
Anti-FCRL4 Antibody
Anti-FCHO1 Antibody
Anti-FCGR3A Antibody
Anti-FCGR2B Antibody
Anti-FCGR2A Antibody
Anti-FCGR2A Antibody
Anti-FCER2 Antibody
Anti-FCER1A Antibody
Anti-FCAR Antibody
Anti-FBXW7 Antibody
Anti-FBXW4 Antibody
Anti-FBXW12 Antibody
Anti-FBXO44 Antibody
Anti-FBXO44 Antibody
Copyright@ 2003-2024
上海拜力生物科技有限公司
版权所有
本公司网站所展示销售的产品仅供科研!
沪ICP备08023583号-12
沪公网安备 31011202007337号