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Antibodies
Anti-ERK1/2 (phospho-T202/Y204) Antibody
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产品名称:
Anti-ERK1/2 (phospho-T202/Y204) Antibody
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简单介绍
Anti-ERK1/2 (phospho-T202/Y204)
Antibody
Anti-ERK1/2 (phospho-T202/Y204) Antibody
的详细介绍
Overview
Name:
Anti-ERK1/2 (phospho-T202/Y204)
Antibody
See all ERK1 primary antibodies
Description:
Rabbit polyclonal antibody to ERK1/2 (phospho-T202/Y204)
Specificity:
p-ERK1/2 (T202/Y204) pAb detects endogenous levels of ERK1 protein when phosphorylated at threonine 202 and tyrosine 204, and ERK2 protein when phosphorylated at threonine 185 and tyrosine 187.
Applications:
WB, IHC, IF
Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic phosphopeptide derived from human ERK1/2 around the phosphorylation site of Threonine 202/Tyrosine 204.
Host:
Rabbit
Clonality:
Polyclonal
Conjugate:
Unconjugated
Molecular Weight:
~ 42,44 kDa
Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Target
Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse
biolog
ical functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.
Sequence Similarities:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Post-Translational Modification:
Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-204.
Cellular Location:
Cytoplasm. Nucleus.
Autophosphorylation at Thr-207 promotes nuclear localization.
Database Links:
Entrez Gene: 5595?Human
Entrez Gene: 26417?Mouse
Entrez Gene: 50689?Rat
Omim: 601795?Human
SwissProt: P27361?Human
SwissProt: Q63844?Mouse
SwissProt: P21708?Rat
Unigene: 861?Human
Unigene: 8385?Mouse
Unigene: 2592?Rat
Synonyms:
ERK Antibody
ERK 1 Antibody
ERK-1 Antibody
ERK1 Antibody
ERT 2 Antibody
ERT2 Antibody
Extracellular Signal Regulated Kinase 1 Antibody
Extracellular signal related kinase Antibody
Extracellular signal related kinase 1 Antibody
Extracellular signal-regulated kinase 1 Antibody
HGNC6877 Antibody
HS44KDAP Antibody
HUMKER1A Antibody
Insulin Stimulated MAP2 Kinase Antibody
Insulin-stimulated MAP2 kinase Antibody
MAP Kinase Antibody
MAP kinase 1 Antibody
MAP kinase 3 Antibody
MAP kinase isoform p44 Antibody
MAPK Antibody
MAPK 1 Antibody
MAPK 3 Antibody
MAPK1 Antibody
Mapk3 Antibody
MGC20180 Antibody
Microtubule Associated Protein 2 Kinase Antibody
Microtubule-associated protein 2 kinase Antibody
Mitogen Activated Protein Kinase 3 Antibody
Mitogen-activated protein kinase 1 Antibody
Mitogen-activated protein kinase 3 Antibody
MK03_HUMAN Antibody
OTTHUMP00000174538 Antibody
OTTHUMP00000174541 Antibody
p44 ERK1 Antibody
p44 MAPK Antibody
p44-ERK1 Antibody
p44-MAPK Antibody
P44ERK1 Antibody
P44MAPK Antibody
PRKM 3 Antibody
PRKM3 Antibody
Protein Kinase Mitogen Activated 3 Antibody
Information:
Target information shown above is from the UniProt Consortium.
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