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Antibodies
Anti-MMP2 Antibody
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产品名称:
Anti-MMP2 Antibody
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简单介绍
Anti-MMP2
Antibody
Anti-MMP2 Antibody
的详细介绍
Overview
Name:
Anti-MMP2
Antibody
See all MMP2 primary antibodies
Description:
Rabbit polyclonal antibody to MMP2.
Applications:
WB, ICC/IF, IHC
Dilutions:
WB: 1:10,000. IF/ICC and IHC: 1:500-1:1,000.
Reactivity:
Human, Horse, Cow, Porcine, Chicken, Rat, Mouse
Immunogen:
Human C-terminal peptide (aa. 475-490).
Host:
Rabbit
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Unconjugated
Purification:
Immunogen affinity purified.
Concentration:
1 mg/ml
Product Form:
Liquid
Storage:
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Target
Function:
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity).
Sequence Similarities:
Belongs to the peptidase M10A family.
Post-Translational Modification:
Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro (By similarity).
Cellular Location:
Secreted > Extracellular space > Extracellular matrix. Membrane. Nucleus.
Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes (By similarity).
Database Links:
Entrez Gene: 386583386583?Chicken
Entrez Gene: 282872?Cow
Entrez Gene: 4313?Human
Entrez Gene: 17390?Mouse
Entrez Gene: 397391?Pig
Entrez Gene: 81686?Rat
Omim: 120360?Human
SwissProt: Q90611?Chicken
SwissProt: Q9GLE5?Cow
SwissProt: P08253?Human
SwissProt: P33434?Mouse
SwissProt: P33436?Rat
Unigene: 513617?Human
Unigene: 29564?Mouse
Unigene: 6422?Rat
Synonyms:
72 kDa gelatinase Antibody
72 kDa type IV collagenase Antibody
72kD type IV collagenase Antibody
CLG 4 Antibody
CLG 4A Antibody
CLG4 Antibody
CLG4A Antibody
Collagenase Type 4 alpha Antibody
Collagenase type IV A Antibody
EC 3.4.24.24 Antibody
Gelatinase A Antibody
Gelatinase alpha Antibody
Gelatinase neutrophil Antibody
Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Antibody
Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase Antibody
Matrix metalloproteinase 2 Antibody
Matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IV collagenase) Antibody
Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Antibody
Matrix metalloproteinase II Antibody
Matrix metalloproteinase-2 Antibody
MMP 2 Antibody
MMP II Antibody
MMP-2 Antibody
MMP2 Antibody
MMP2_HUMAN Antibody
MONA Antibody
Neutrophil gelatinase Antibody
PEX Antibody
TBE 1 Antibody
TBE-1 Antibody
Information:
Target information shown above is from the UniProt Consortium.
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