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Antibodies
Anti-CD63 Antibody
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产品名称:
Anti-CD63 Antibody
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简单介绍
Anti-CD63
Antibody
Anti-CD63 Antibody
的详细介绍
Overview
Name:
Anti-CD63
Antibody
See all CD63 primary antibodies
Description:
Mouse monoclonal (MEM-259) antibody to CD63.
Specificity:
The antibody MEM-259 reacts with CD63 (LAMP-3), a 40-60 kDa tetraspan glycoprotein expressed by granulocytes, platelets, T cells, monocytes/macrophages and endothelial cells. Cell surface exposition of CD63 is usually activation-dependent.
Applications:
FC, IP, IHC-P, ICC
Reactivity:
Human
Immunogen:
HPB-ALL T cell line.
Host:
Mouse
Clonality:
Monoclonal
Clone:
MEM-259
Isotype:
IgG1
Conjugate:
Unconjugated
Purification:
Protein A chromatography.
Concentration:
1 mg/ml
Purity:
> 95% (by SDS-PAGE)
Product Form:
Liquid
Formulation:
Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage:
Store at 2-8°C.
Target
Function:
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Tissue Specificity:
Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.
Sequence Similarities:
Belongs to the tetraspanin (TM4SF) family.
Post-Translational Modification:
Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).
Cellular Location:
Cell membrane. Lysosome membrane. Late endosome membrane. Endosome > Multivesicular body. Melanosome. Secreted > Exosome. Cell surface.
Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155). Located in platelet dense granules (PubMed:7682577). Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903).
Database Links:
Entrez Gene: 967?Human
Omim: 155740?Human
SwissProt: P08962?Human
Unigene: 445570?Human
Synonyms:
Lysosomal associated membrane protein 3 Antibody
CD 63 Antibody
CD63 Antibody
CD63 antigen Antibody
CD63 antigen (melanoma 1 antigen) Antibody
CD63 antigen melanoma 1 antigen Antibody
CD63 molecule Antibody
CD63_HUMAN Antibody
gp55 Antibody
Granulophysin Antibody
LAMP 3 Antibody
LAMP-3 Antibody
LAMP3 Antibody
LIMP Antibody
Lysosomal-associated membrane protein 3 Antibody
Lysosome associated membrane glycoprotein 3 Antibody
Mast cell antigen AD1 Antibody
ME491 Antibody
Melanoma 1 antigen Antibody
Melanoma associated antigen ME491 Antibody
Melanoma associated antigen MLA1 Antibody
Melanoma-associated antigen ME491 Antibody
MGC72893 Antibody
MLA 1 Antibody
MLA1 Antibody
NGA Antibody
Ocular melanoma associated antigen Antibody
Ocular melanoma-associated antigen Antibody
OMA81H Antibody
PTLGP40 Antibody
Tetraspanin 30 Antibody
Tetraspanin-30 Antibody
Tspan 30 Antibody
Tspan-30 Antibody
TSPAN30 Antibody
Information:
Target information shown above is from the UniProt Consortium.
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