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Anti-CD11b Antibody

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产品名称: Anti-CD11b Antibody
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Anti-CD11b Antibody


Anti-CD11b Antibody  的详细介绍
Name: Anti-CD11b Antibody
See all CD11b primary antibodies
Description: Rat monoclonal (M1/70) antibody to CD11b.
Specificity: The rat monoclonal antibody M1/70 detects CD11b (integrin alphaM subunit), a type I transmembrane protein mainly expressed on monocytes/macrophages, granulocytes and NK-cells, which associates with CD18 to form Mac-1 integrin that plays important role in cell-cell interactions.
Applications: FC, IP, IHC-Fr, FUNC
Reactivity: Human, Non-Human Primates, Mouse, Rabbit
Immunogen: B10 mouse spleen cells enriched for T cells.
Host: Rat
Clonality: Monoclonal
Clone: M1/70
Isotype: IgG2b
Conjugate: Unconjugated
Purification: Protein G chromatography.
Concentration: 1 mg/ml
Purity: > 95% (by SDS-PAGE)
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.4, without Azide (0.2 μm filter sterilised). Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
Storage: Store at 2-8°C.
Function: Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:8986723, PubMed:9382884, PubMed:9862668). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (PubMed:8986723). May play a role in mast cell development (PubMed:9862668).
Tissue Specificity: Predominantly expressed in monocytes and granulocytes (PubMed:3887182, PubMed:8986723). Expressed in a subset of peritoneal mast cells (PubMed:9862668).
Sequence Similarities: Belongs to the integrin alpha chain family.
Cellular Location: Cell membrane. Membrane raft.
Database Links:
  • Entrez Gene: 3684?Human
  • Entrez Gene: 16409?Mouse
  • Entrez Gene: 100351865?Rabbit
  • Omim: 120980?Human
  • SwissProt: P11215?Human
  • SwissProt: P05555?Mouse
  • Unigene: 172631?Human
  • Unigene: 262106?Mouse
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    Synonyms:
  • antigen CD11b (p170) Antibody
  • Antigen CD11b p170 Antibody
  • CD11 antigen like family member B Antibody
  • CD11 antigen-like family member B Antibody
  • CD11b Antibody
  • CD11b/CD18 Antibody
  • CD49d Antibody
  • Cell surface glycoprotein MAC-1 subunit alpha Antibody
  • Complement component 3 receptor 3 subunit Antibody
  • Complement Component Receptor 3 Alpha Antibody
  • Complement receptor type 3, alpha subunit Antibody
  • CR 3 alpha chain Antibody
  • CR 3 alpha chain (CR3A) Antibody
  • CR-3 alpha chain Antibody
  • CR3 Antibody
  • CR3A Antibody
  • F730045J24Rik Antibody
  • Integrin Alpha M Antibody
  • Integrin alpha M chain Antibody
  • Integrin alpha-M Antibody
  • Integrin beta 2 alpha subunit Antibody
  • Integrin subunit alpha M Antibody
  • integrin, alpha M (complement component 3 receptor 3 subunit) Antibody
  • ITAM_HUMAN Antibody
  • ITGAM Antibody
  • Leukocyte adhesion receptor MO1 Antibody
  • Ly-40 Antibody
  • MAC 1 Antibody
  • Mac-1a Antibody
  • MAC1 Antibody
  • Mac1, alpha subunit Antibody
  • MAC1A Antibody
  • Macrophage antigen alpha polypeptide Antibody
  • MGC117044 Antibody
  • Mo1, alpha subunit Antibody
  • MO1A Antibody
  • Neutrophil adherence receptor Antibody
  • Neutrophil adherence receptor alpha M subunit Antibody
  • SLEB6 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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