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Anti-E2F4 Antibody

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产品名称: Anti-E2F4 Antibody
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简单介绍

Anti-E2F4 Antibody


Anti-E2F4 Antibody  的详细介绍
Name: Anti-E2F4 Antibody
See all E2F4 primary antibodies
Description: Goat polyclonal antibody to E2F4.
Applications: ELISA, WB
Reactivity: Human, Porcine
Immunogen: Synthetic peptide corresponding to Human E2F4 (internal region).
Sequence: C-PKELSEIFDPTR
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.
Tissue Specificity: Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Sequence Similarities: Belongs to the E2F/DP family.
Post-Translational Modification: Differentially phosphorylated in vivo.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 1874 Human
  • Entrez Gene: 100522677 Pig
  • Omim: 600659 Human
  • SwissProt: Q16254 Human
  • Unigene: 108371 Human
    		•
    Synonyms:
  • E2F 4 Antibody
  • E2F transcription factor 4 Antibody
  • E2F transcription factor 4 p107/p130 binding Antibody
  • E2F-4 Antibody
  • E2F4 Antibody
  • E2F4_HUMAN Antibody
  • p107/p130 binding protein Antibody
  • Transcription factor E2F 4 Antibody
  • Transcription factor E2F4 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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