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Anti-FOXL2 Antibody

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产品名称: Anti-FOXL2 Antibody
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Anti-FOXL2 Antibody


Anti-FOXL2 Antibody  的详细介绍
Name: Anti-FOXL2 Antibody
See all FOXL2 primary antibodies
Description: Goat polyclonal antibody to FOXL2.
Applications: ELISA, WB, IHC
Reactivity: Human, Mouse
Immunogen: Synthetic peptide corresponding to Human FOXL2 (C terminal).
Sequence: C-DSKTGALHSRLDL
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 μg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Is a regulator of CYP19 expression. Is a transcriptional repressor of STAR. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element.
Tissue Specificity: Expressed in the mesenchyme of developing eyelids. Expressed in ovaries throughout development and *****hood, localized to the undifferentiated granulosa cells in small and medium follicles as well as cumulus cells of preovulatory follicles. Expressed in the pituitary.
Post-Translational Modification: Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 668?Human
  • Entrez Gene: 26927?Mouse
  • Omim: 605597?Human
  • SwissProt: P58012?Human
  • SwissProt: O88470?Mouse
  • Unigene: 289292?Human
  • Unigene: 151239?Mouse
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    Synonyms:
  • Blepharophimosis Antibody
  • Blepharophimosis epicanthus inversus and ptosis Antibody
  • Blepharophimosis epicanthus inversus and ptosis 1 Antibody
  • BPES Antibody
  • BPES 1 Antibody
  • BPES1 Antibody
  • Epicanthus inversus and ptosis 1 Antibody
  • Forkhead box L2 Antibody
  • Forkhead box protein L2 Antibody
  • Forkhead transcription factor FOXL2 Antibody
  • FOX L2 Antibody
  • FOXL 2 Antibody
  • FOXL2 Antibody
  • FOXL2_HUMAN Antibody
  • PFRK Antibody
  • PINTO Antibody
  • PITUITARY FORKHEAD FACTOR Antibody
  • POF 3 Antibody
  • POF3 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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