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Anti-CD31 Antibody

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产品名称: Anti-CD31 Antibody
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Anti-CD31 Antibody


Anti-CD31 Antibody  的详细介绍
Name: Anti-CD31 Antibody
See all CD31 primary antibodies
Description: Mouse monoclonal (JC70A) antibody to CD31.
Specificity: Human CD31, Formalin-resistant epitope on a 130 kDa glycoprotein chain, reactivity confirmed on V. Internat. Workshop on Leucocyte Typing (Boston 1993).
Applications: IHC
Reactivity: Human
Immunogen: Spleen cell membrane preparation of hairy cell leukemia affected patient.
Host: Mouse
Clonality: Monoclonal
Clone: JC70A
Isotype: IgG1
Conjugate: Unconjugated
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.3, with 0.09% Sodium Azide.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes: This antibody is frequently used for the evaluation of angiogenesis in proliferating tumours (i.e. in mamma carcinoma, colorectal carcinoma and lung cancer).
Function: Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).
Tissue Specificity: Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level).
Post-Translational Modification: Phosphorylated on Ser and Tyr residues after cellular activation. Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation (By similarity). In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation.
Cellular Location: Cell membrane. Membrane raft. Cell junction.

Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Database Links:
  • Entrez Gene: 5175?Human
  • Omim: 173445?Human
  • SwissProt: P16284?Human
  • Unigene: 376675?Human
  • Unigene: 514412?Human
    		•
    Synonyms:
  • Adhesion molecule Antibody
  • CD31 Antibody
  • CD31 antigen Antibody
  • CD31 EndoCAM Antibody
  • EndoCAM Antibody
  • FLJ34100 Antibody
  • FLJ58394 Antibody
  • GPIIA Antibody
  • GPIIA' Antibody
  • GPIIA'' Antibody
  • HEC7 Antibody
  • Leukocyte surface protein Antibody
  • PECA1 Antibody
  • PECA1_HUMAN Antibody
  • PECAM Antibody
  • PECAM 1 Antibody
  • PECAM 1 CD31 EndoCAM Antibody
  • PECAM-1 Antibody
  • Pecam1 Antibody
  • Platelet and endothelial cell adhesion molecule 1 Antibody
  • Platelet endothelial cell adhesion molecule Antibody
  • Platelet/endothelial cell adhesion molecule Antibody
  • Platelet/endothelial cell adhesion molecule 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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