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Anti-Bcl-2 (P65) Antibody

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产品名称: Anti-Bcl-2 (P65) Antibody
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Anti-Bcl-2 (P65) Antibody


Anti-Bcl-2 (P65) Antibody  的详细介绍
Name: Anti-Bcl-2 (P65) Antibody
See all Bcl-2 primary antibodies
Description: Rabbit polyclonal antibody to Bcl-2 (P65)
Specificity: Bcl-2 (P65) pAb detects endogenous levels of Bcl-2 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 31-80 of Human Bcl-2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 26 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Tissue Specificity: Expressed in a variety of tissues.
Sequence Similarities: Belongs to the Bcl-2 family.
Post-Translational Modification: Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity).
Cellular Location: Mitochondrion outer membrane. Nucleus membrane. Endoplasmic reticulum membrane.
Database Links:
  • Entrez Gene: 596?Human
  • Entrez Gene: 12043?Mouse
  • Entrez Gene: 24224?Rat
  • Omim: 151430?Human
  • SwissProt: P10415?Human
  • SwissProt: P10417?Mouse
  • SwissProt: P49950?Rat
  • Unigene: 150749?Human
  • Unigene: 257460?Mouse
  • Unigene: 9996?Rat
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    Synonyms:
  • Apoptosis regulator Bcl 2 Antibody
  • Apoptosis regulator Bcl-2 Antibody
  • Apoptosis regulator Bcl2 Antibody
  • AW986256 Antibody
  • B cell CLL/lymphoma 2 Antibody
  • B cell leukemia/lymphoma 2 Antibody
  • Bcl-2 Antibody
  • Bcl2 Antibody
  • BCL2_HUMAN Antibody
  • C430015F12Rik Antibody
  • D630044D05Rik Antibody
  • D830018M01Rik Antibody
  • Leukemia/lymphoma, B-cell, 2 Antibody
  • Oncogene B-cell leukemia 2 Antibody
  • PPP1R50 Antibody
  • Protein phosphatase 1, regulatory subunit 50 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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