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Anti-TIRAP Antibody

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产品名称: Anti-TIRAP Antibody
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简单介绍

Anti-TIRAP Antibody


Anti-TIRAP Antibody  的详细介绍
Name: Anti-TIRAP Antibody
See all TIRAP primary antibodies
Description: Goat polyclonal antibody to TIRAP.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human TIRAP (C terminal).
Sequence: C-EGEGERDSATVSDL
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
Tissue Specificity: Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.
Post-Translational Modification: Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK.
Cellular Location: Cytoplasm. Cell membrane. Membrane.

Colocalizes with DAB2IP at the plasma membrane.
Database Links:
  • Entrez Gene: 114609 Human
  • GenBank: AF378129 Human
  • GenBank: AF378130 Human
  • Omim: 606252 Human
  • SwissProt: P58753 Human
  • Unigene: 537126 Human
    		•
    Synonyms:
  • Adapter protein wyatt Antibody
  • FLJ42305 Antibody
  • MAL Antibody
  • MyD88 adapter like protein Antibody
  • TIR domain containing adapter protein Antibody
  • TIRAP Antibody
  • Toll interleukin 1 receptor (TIR) domain containing adaptor protein Antibody
  • Toll interleukin 1 receptor domain containing adapter protein Antibody
  • Toll like receptor adaptor protein Antibody
  • Wyatt Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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