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Anti-GAPDH Antibody

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产品名称: Anti-GAPDH Antibody
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简单介绍

Anti-GAPDH Antibody


Anti-GAPDH Antibody  的详细介绍
Name: Anti-GAPDH Antibody
See all GAPDH primary antibodies
Description: Rabbit polyclonal antibody to GAPDH
Specificity: GAPDH pAb detects endogenous levels of GAPDH protein.
Applications: WB
Reactivity: Human, Mouse, Rat Mammals
Immunogen: Recombinant full length Human GAPDH.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 36 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (By similarity).
Tissue Specificity: High levels in skeletal muscle and heart, low levels in liver, brain, and kidney.
Sequence Similarities: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Post-Translational Modification: S-nitrosylation of Cys-150 leads to interaction with SIAH1, followed by translocation to the nucleus. The effect of S-nitrosylation on enzymatic activity is unclear: according to some authors, it inhibits enzymatic activity and increases endogenous ADP-ribosylation, inhibiting the enzyme in a non-reversible manner (PubMed:8626764). According to others, it does not affect glycolysis (PubMed:15951807). ADP-ribosylation is likely to be a pathophysiological event associated with inhibition of gluconeogenesis. S-nitrosylation of Cys-245 is induced by interferon-gamma and LDL(ox) implicating the iNOS-S100A8/9 transnitrosylase complex and seems to prevent interaction with phosphorylated RPL13A and to interfere with GAIT complex activity (By similarity).
Cellular Location: Cytoplasm > Cytosol. Cytoplasm > Cytoskeleton. Nucleus.

Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal. Colocalizes with CHP1 to small punctate structures along the microtubules tracks.
Database Links:
  • Entrez Gene: 2597 Human
  • Entrez Gene: 100042025 Mouse
  • Entrez Gene: 14433 Mouse
  • Entrez Gene: 24383 Rat
  • Entrez Gene: 685186 Rat
  • Omim: 138400 Human
  • SwissProt: P04406 Human
  • SwissProt: P16858 Mouse
  • SwissProt: P04797 Rat
  • Unigene: 544577 Human
  • Unigene: 592355 Human
  • Unigene: 598320 Human
  • Unigene: 304088 Mouse
  • Unigene: 309092 Mouse
  • Unigene: 317779 Mouse
  • Unigene: 343110 Mouse
  • Unigene: 392463 Mouse
  • Unigene: 392480 Mouse
  • Unigene: 414470 Mouse
  • Unigene: 458138 Mouse
  • Unigene: 458416 Mouse
  • Unigene: 475698 Mouse
  • Unigene: 129558 Rat
  • Unigene: 91450 Rat
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    Synonyms:
  • 38 kDa BFA-dependent ADP-ribosylation substrate Antibody
  • aging associated gene 9 protein Antibody
  • Aging-associated gene 9 protein Antibody
  • BARS-38 Antibody
  • cb609 Antibody
  • EC 1.2.1.12 Antibody
  • Epididymis secretory sperm binding protein Li 162eP Antibody
  • G3PD Antibody
  • G3PDH Antibody
  • G3P_HUMAN Antibody
  • GAPD Antibody
  • GAPDH Antibody
  • Glyceraldehyde 3 phosphate dehydrogenase Antibody
  • Glyceraldehyde-3-phosphate dehydrogenase Antibody
  • HEL S 162eP Antibody
  • HEL-S-162eP Antibody
  • KNC-NDS6 Antibody
  • MGC102544 Antibody
  • MGC102546 Antibody
  • MGC103190 Antibody
  • MGC103191 Antibody
  • MGC105239 Antibody
  • MGC127711 Antibody
  • MGC88685 Antibody
  • OCAS, p38 component Antibody
  • OCT1 coactivator in S phase, 38-KD component Antibody
  • peptidyl cysteine S nitrosylase GAPDH Antibody
  • Peptidyl-cysteine S-nitrosylase GAPDH Antibody
  • wu:fb33a10 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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