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Anti-PINX1 Antibody

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产品名称: Anti-PINX1 Antibody
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简单介绍

Anti-PINX1 Antibody


Anti-PINX1 Antibody  的详细介绍
Name: Anti-PINX1 Antibody
See all PINX1 primary antibodies
Description: Goat polyclonal antibody to PINX1.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human PINX1 (N terminal).
Sequence: SMLAERRRKQKWAV-C
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
Tissue Specificity: Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.
Sequence Similarities: Belongs to the PINX1 family.
Cellular Location: Nucleus. Nucleus > Nucleolus. Chromosome > Telomere. Chromosome > Centromere > Kinetochore.

Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
Database Links:
  • Entrez Gene: 54984 Human
  • Omim: 606505 Human
  • SwissProt: Q96BK5 Human
  • Unigene: 490991 Human
  • Unigene: 583894 Human
    		•
    Synonyms:
  • 67-11-3 protein Antibody
  • FLJ20565 Antibody
  • Hepatocellular carcinoma-related putative tumor suppressor Antibody
  • Liver-related putative tumor suppressor Antibody
  • LPTL Antibody
  • LPTS Antibody
  • MGC8850 Antibody
  • OTTHUMP00000224984 Antibody
  • OTTHUMP00000224985 Antibody
  • OTTHUMP00000224986 Antibody
  • OTTHUMP00000225053 Antibody
  • OTTHUMP00000225054 Antibody
  • PIN2 interacting protein 1 Antibody
  • Pin2-interacting protein X1 Antibody
  • PIN2/TERF1-interacting telomerase inhibitor 1 Antibody
  • PINX1 Antibody
  • PINX1_HUMAN Antibody
  • Protein 67-11-3 Antibody
  • TRF1-interacting protein 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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