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Antibodies
Anti-GAPDH Antibody
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产品名称:
Anti-GAPDH Antibody
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简单介绍
Anti-GAPDH
Antibody
Anti-GAPDH Antibody
的详细介绍
Overview
Name:
Anti-GAPDH
Antibody
See all GAPDH primary antibodies
Description:
Mouse monoclonal (1D4) antibody to GAPDH.
Applications:
WB, ICC/IF, IHC
Dilutions:
WB: 1:1,000. IF/IHC: 1:100.
Reactivity:
Human, Horse, Cow, Porcine, Chicken, Rat, Mouse
Immunogen:
Whole protein purified from pig.
Host:
Mouse
Clonality:
Monoclonal
Clone:
1D4
Isotype:
IgM
Conjugate:
Unconjugated
Purification:
Immunogen affinity purified.
Concentration:
1 mg/ml
Product Form:
Liquid
Formulation:
Supplied in Phosphate Buffered Saline with 50% Glycerol and 5mM Sodium Azide.
Storage:
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Target
Function:
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (By similarity).
Tissue Specificity:
High levels in skeletal muscle and heart, low levels in liver, brain, and kidney.
Sequence Similarities:
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Post-Translational Modification:
S-nitrosylation of Cys-150 leads to interaction with SIAH1, followed by translocation to the nucleus. The effect of S-nitrosylation on enzymatic activity is unclear: according to some authors, it inhibits enzymatic activity and increases endogenous ADP-ribosylation, inhibiting the enzyme in a non-reversible manner (PubMed:8626764). According to others, it does not affect glycolysis (PubMed:15951807). ADP-ribosylation is likely to be a pathophysiological event associated with inhibition of gluconeogenesis. S-nitrosylation of Cys-245 is induced by interferon-gamma and LDL(ox) implicating the iNOS-S100A8/9 transnitrosylase complex and seems to prevent interaction with phosphorylated RPL13A and to interfere with GAIT complex activity (By similarity).
Cellular Location:
Cytoplasm > Cytosol. Cytoplasm > Cytoskeleton. Nucleus.
Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal. Colocalizes with CHP1 to small punctate structures along the microtubules tracks.
Database Links:
Entrez Gene: 374193?Chicken
Entrez Gene: 281181?Cow
Entrez Gene: 2597?Human
Entrez Gene: 100042025?Mouse
Entrez Gene: 14433?Mouse
Entrez Gene: 396823?Pig
Entrez Gene: 24383?Rat
Entrez Gene: 685186?Rat
Omim: 138400?Human
SwissProt: P00356?Chicken
SwissProt: P10096?Cow
SwissProt: P04406?Human
SwissProt: P16858?Mouse
SwissProt: P00355?Pig
SwissProt: P04797?Rat
Unigene: 544577?Human
Unigene: 592355?Human
Unigene: 598320?Human
Unigene: 304088?Mouse
Unigene: 309092?Mouse
Unigene: 317779?Mouse
Unigene: 343110?Mouse
Unigene: 392463?Mouse
Unigene: 392480?Mouse
Unigene: 414470?Mouse
Unigene: 458138?Mouse
Unigene: 458416?Mouse
Unigene: 475698?Mouse
Unigene: 129558?Rat
Unigene: 91450?Rat
Synonyms:
38 kDa BFA-dependent ADP-ribosylation substrate Antibody
aging associated gene 9 protein Antibody
Aging-associated gene 9 protein Antibody
BARS-38 Antibody
cb609 Antibody
EC 1.2.1.12 Antibody
Epididymis secretory sperm binding protein Li 162eP Antibody
G3PD Antibody
G3PDH Antibody
G3P_HUMAN Antibody
GAPD Antibody
GAPDH Antibody
Glyceraldehyde 3 phosphate dehydrogenase Antibody
Glyceraldehyde-3-phosphate dehydrogenase Antibody
HEL S 162eP Antibody
HEL-S-162eP Antibody
KNC-NDS6 Antibody
MGC102544 Antibody
MGC102546 Antibody
MGC103190 Antibody
MGC103191 Antibody
MGC105239 Antibody
MGC127711 Antibody
MGC88685 Antibody
OCAS, p38 component Antibody
OCT1 coactivator in S phase, 38-KD component Antibody
peptidyl cysteine S nitrosylase GAPDH Antibody
Peptidyl-cysteine S-nitrosylase GAPDH Antibody
wu:fb33a10 Antibody
Information:
Target information shown above is from the UniProt Consortium.
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