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Anti-PCNA Antibody

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产品名称: Anti-PCNA Antibody
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简单介绍

Anti-PCNA Antibody


Anti-PCNA Antibody  的详细介绍
Name: Anti-PCNA Antibody
See all PCNA primary antibodies
Description: Mouse monoclonal (PC10) antibody to PCNA.
Applications: IHC
Reactivity: Human, Rat
Immunogen: Recombinant rat PCNA (Protein A expression vector pR1T2T).
Host: Mouse
Clonality: Monoclonal
Clone: PC10
Isotype: IgG2a
Conjugate: Unconjugated
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.3, with 0.09% Sodium Azide.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (By similarity).
Sequence Similarities: Belongs to the PCNA family.
Post-Translational Modification: Phosphorylated. Phosphorylation at Tyr-211 by EGFR stabilizes chromatin-associated PCNA (By similarity).
Cellular Location: Nucleus.

Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (By similarity).
Database Links:
  • Entrez Gene: 5111?Human
  • Entrez Gene: 25737?Rat
  • Omim: 176740?Human
  • SwissProt: P12004?Human
  • SwissProt: P04961?Rat
  • Unigene: 147433?Human
  • Unigene: 728886?Human
  • Unigene: 223?Rat
    		•
    Synonyms:
  • ATLD2 Antibody
  • cb16 Antibody
  • Cyclin Antibody
  • DNA polymerase delta auxiliary protein Antibody
  • etID36690.10 Antibody
  • fa28e03 Antibody
  • fb36g03 Antibody
  • HGCN8729 Antibody
  • MGC8367 Antibody
  • Mutagen-sensitive 209 protein Antibody
  • OTTHUMP00000030189 Antibody
  • OTTHUMP00000030190 Antibody
  • PCNA Antibody
  • Pcna/cyclin Antibody
  • PCNAR Antibody
  • PCNA_HUMAN Antibody
  • Polymerase delta accessory protein Antibody
  • Proliferating cell nuclear antigen Antibody
  • wu:fa28e03 Antibody
  • wu:fb36g03 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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