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Reactivity: CD300e (IREM-2) expression appears at the end of maturation of monocytes, even after the complete acquisition of CD14.
Specificity: The Anti-CD300e is specific for monocytic lineage and myeloid dendritic cells. In normal peripheral blood it should be positive in at least 80% of monocytes and in bone marrow in 50%. The antibody can be used to classify myeloid leukaemias, especially those with monocytic component.
The identification of a novel activating Ig-like receptor, expressed on monocytes and a subset of dendritic cells (DC), has been termed immunune receptor expressed by myeloid cells.
IREM-2 belongs to the CMRF-35 family located in human chromosome 17. This 34 KDa Ig-like-domain is an activating receptor that interacts with ITAM containing adaptor proteins like DAP12 through it is charged residues in cytoplasmic domain. CD300e expression is found exclusively on monocytes and myeloid DC’s. In normal peripheral blood it should be positive in at least 80% of Monocytes.?
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