ACO1 Antibody

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产品名称: ACO1 Antibody

产品型号: abx004618

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简单介绍

ACO1 Antibody

ACO1 Antibody 的详细介绍

ACO1 Antibody is a Rabbit Polyclonal antibody against ACO1. The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants.

Target	ACO1
Reactivity	Human, Mouse, Rat, Hamster
Origin	Human
Host	Rabbit
Clonality	Polyclonal
Tested Applications	WB, IHC
Recommended dilutions	WB: 1/500 - 1/1000, IP: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	A synthetic peptide of human ACO1.
Purification	Affinity purified.
Isotype	IgG
Conjugation	Unconjugated
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight	98 kDa
Swiss Prot	P21399
GeneID	48
Gene Symbol	ACO1
Enzyme Commission Number	EC 4.2.1.3, EC 4.2.1
Concentration	> 1 mg/ml
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

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