ABL1/2 (pY393/429) Antibody

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产品名称: ABL1/2 (pY393/429) Antibody

产品型号: abx000333

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ABL1/2 (pY393/429) Antibody

ABL1/2 (pY393/429) Antibody 的详细介绍

ABL1/2 (pY393/429) Antibody is a Rabbit Polyclonal antibody against ABL1/2 (pY393/429). Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Target	ABL1/2 (pY393/429)
Reactivity	Human, Mouse
Origin	Human
Host	Rabbit
Clonality	Polyclonal
Tested Applications	WB, IHC, IF/ICC
Recommended dilutions	WB: 1/500 - 1/1000, IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y393/429 of human ABL1/2.
Purification	Affinity purified.
Isotype	IgG
Conjugation	Unconjugated
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight	210 kDa
Swiss Prot	P00519 P42684
GeneID	25/27
Gene Symbol	ABL1, ABL2
Concentration	> 1 mg/ml
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

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