ABCG2 Antibody

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产品名称: ABCG2 Antibody

产品型号: abx015756

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简单介绍

ABCG2 Antibody

ABCG2 Antibody 的详细介绍

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters.ABC proteins transport various molecules across extra- and intra-cellular membranes.ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).This protein is a member of the White subfamily.Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance.It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure.Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.Tissue specificity: Highly expressed in placenta.Low expression in small intestine, liver and colon.

Target	ABCG2
Reactivity	Human, Mouse, Monkey
Host	Mouse
Clonality	Monoclonal
Tested Applications	ELISA, WB, IF/ICC
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Purified recombinant fragment of human ABCG2 expressed in E. coli.
Isotype	IgG₁
Conjugation	Unconjugated
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight	72 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

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