EMFRET Analytics GmbH公司 EMFRET Analytics GmbH代理 EMFRET Analytics GmbH中国代理 EMFRET Analytics GmbH**代理
德国EMFRET公司专注心血管和血液系统研究用抗体研发和生产，供应的抗体包括清除血液中血小板、流式细胞术鉴定分析小鼠血小板表面糖蛋白，EMFRET公司的抗体不仅适用于流失分析、WB检测，还可用于免疫组化/免疫荧光及免疫共沉淀检测。
Antibodies for Platelet Depletion in Mice
# R300
Product Information
Catalog Number:
R300 (lot # M)
Isotype:
Rat IgG (Wistar)
Contents:
0.5 mg purified immunoglobulins in PBS, sterile filtered
Concentration:
0.5 mg/ml
For research use only, not for diagnostic or therapeutic use. This product is no medical device.
Specificity: This antibody preparation contains a mixture of purified rat monoclonal antibodies
directed against mouse GPIba (CD42b). Targeting of this receptor with divalent IgGs results in profound and irreversible Fc-independent platelet depletion in mice1,2. Platelet depletion is frequently used to study the general role of platelets in (patho-) physiology3.
Preparation and Storage: The antibodies were purified from hybridoma cell culture supernatant by Protein G-Sepharose chromatography and contain < 0.00025 ng/μg (< 0.0025 EU/μg) protein endotoxin. Stable for six months from date of shipment when stored at 4°C. KEEP STERILE, the preparation contains no preservative. Aliquots can be stored at -20°C for at least one year. Avoid repeated freezing and thawing.
Usage: This preparation is optimized to reduce the platelet count by >95% within 60 minutes after intravenous injection of 2 μg/g bodyweight. It is recommended to inject the antibodies in a volume of 100-200 μl (diluted with sterile PBS).
Depletion of mouse platelets by anti-GPIba treatment
Wild type mice received 2 or 4 μg/g platelet depletion antibodies in 200 μl sterile PBS intravenously and platelet counts were determined at the indicated time points. Results are mean ± s.d. of 6 mice per group.
其它产品信息如下：
货号
抗原类型
克隆方式
表型
产品形式
应用
规格
C301
清除小鼠血小板
polyclonal non-immune rat immunoglobulins
Rat IgG
纯化
0.5 mg
D200
双色分析血小板活性
Wug.E9 JON/A
Rat IgG2b/IgG1
FITC、PE
流式细胞术
2 x 1.0 ml; 200 tests
M011-0
GPVI
JAQ1
Rat IgG2a
IP, IHC, WB
0.1 mg
M011-1
FITC
FC, IHC
1.5 ml; 300 tests
M021-0
Integrin alphaIIbbeta3 (GPIIb/IIIa, CD41/CD61)
Leo.H4
Rat IgG2b
purif.
IP, IHC, block
M021-1
M022-0
Leo.A1
Rat IgG1
IP, IHC
M023-2
JON/A
PE
FC (activ. form)
M024-0
Integrin alphaIIb (GPIIb, CD41)
MwReg30
IP, IHC, generation of Fab fragments
6 mg
M025-0
Leo.F2
M025-1
M025-2
M025-3
DyLight 649
M030-0
Integrin beta3 chain (GPIIIa, CD61)
Luc.A5
M031-0
Luc.H11
M031-1
M040-0
GPIbalpha (CD42b)
Xia.G5
M040-1
M040-2
M040-3
M041-0
Xia.H10
M041-1
M042-0
Xia.G7
M042-1
M043-0
Xia.B2
M043-1
M050-0
GPIbbeta (CD42c)
Xia.C3
M050-1
M051-0
GPIX (CD42a)
Xia.B4
M051-1
M060-1
GPV (CD42d)
Gon.C2
M061-1
Gon.G6
M070-0
Integrin alpha2 chain (CD49b, GPIa)
Sam.G4
M070-1
M071-0
Sam.C1
M071-1
M075-0
Sam.C1, Sam.G4, Sam.H9
M080-0
Integrin alpha5 chain (CD49e)
Tap.A12
M080-1
M110-0
CD9
Nyn.H3
M110-1
M120-0
CD31 (PECAM-1)
Pec.H3
M130-0
CD62P (P-selectin)
Wug.E9
M130-1
M130-2
P140-1
fibrinogen
polyclonal
Rabbit IgG
P150-1
von Willebrand Factor (vWF)
P180-1
negative control
1.0 ml; 200 tests
P190-1
P190-2
P190-3
R300
Antibodies for Mouse Platelet Depletion
polyclonal anti-GPIb alpha
platelet depletion
X488
Antibodies for In Vivo Mouse Platelet Labeling
anti - GPIbbeta derivative
DyLight 488
in vivo
100 μg
X649
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