Human CXCL11 Lyophilized Chemokine

点击看大图

如果您对该产品感兴趣的话,可以

产品名称: Human CXCL11 Lyophilized Chemokine

产品型号: IRCXCL11

产品展商: Innov-Research

产品文档: 无相关文档

简单介绍

Human CXCL11 Lyophilized Chemokine

Human CXCL11 Lyophilized Chemokine 的详细介绍

Product Description

Human CXCL11 Lyophilized Chemokine

Recombinant human CXCL11 from Innovative Research is provided as a native untagged protein. This chemokine is expressed in E. coli then processed, refolded and purified to yield the native, secreted form of the mature chemokine. 98 percent pure by SDS-PAGE, HPLC, MALDI-MS and NMR analysis. CXCR3 activity verified by intracellular calcium flux using commercially available CXCR3 expressing cells. Add deionized water to desired volume, aliquot and freeze unused portion. C-X-C motif chemokine 11 (CXCL11) is a 73 amino acid Cys-X-Cys chemokine that induces calcium release in interleukin-activated T-cells and may play a role in skin immune responses and CNS diseases which involve T-cell recruitment. It is also known as interferon gamma-inducible protein 9 (IP-9) and interferon-inducible T-cell alpha chemoattractant (I-TAC). CXCL11 is a ligand for the G protein coupled receptors CXCR3 and CXCR7 and is chemotactic for interleukin-stimulated T-cells but not unstimulated T-cells, neutrophils or monocytes. CXCL11 is expressed at high levels in peripheral blood leukocytes, pancreas and liver astrocytes, moderate levels in the thymus, spleen and lung, and at low levels in the placenta, prostate and small intestine. In skin disorders CXCL11 may also be found in epidermal basal layer keratinocytes. CXCL11 is induced by IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN-gamma is enhanced by TNF in monocytes, dermal fibroblasts and endothelial cells, and by IL-1 in astrocytes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CXC cytokines are chemotactic cytokines characterized by two cysteines separated by one amino acid that induce directed chemotaxis in nearby responsive cells.

Click Here for SDS

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!