Bovine Lactadherin

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产品名称: Bovine Lactadherin

产品型号: IRBLCTDHRN

产品展商: Innov-Research

产品文档: 无相关文档

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Bovine Lactadherin

Bovine Lactadherin 的详细介绍

Product Description

Bovine Lactadherin

Lactadherin is a widely distributed glycoprotein (~ 50 kDa), which was originally characterized due to its association with milk fat/lipid globule membranes. Synonymous names are PAS-6/7, bovine-associated mucoprotein, BA-46, P47, and MFG-E8. Structural hallmarks of lactadherin are the presence of two epidermal growth factor (EGF) homology domains (with an RGD peptide motif in the second EGF domain), and two C domains sharing homology with the discoidin family of lectin domains including the phospholipid-binding domains of blood clotting factors V and VIII. Lactadherin shows preferential binding to phosphatidylserine (L-form) in a calcium independent manner.

Purified lactadherin functions as an anticoagulant by blocking phosphatidylserine-containing membrane sites for blood coagulation proteins. Fluoresence-labeled lactadherin functions as a sensitive probe for exposed phosphatidylserine on nucleated cells and on stimulated platelets. Lactadherin will bind to membranes that have phosphatidylserine content below the threshold for annexin V binding.

Lactadherin is purified from un-pasteurized bovine milk.

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