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Ac-TVASSSTA Octapeptide

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产品名称: Ac-TVASSSTA Octapeptide
产品型号: IPEP-1
产品展商: Innov-Research
产品文档: 无相关文档

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Ac-TVASSSTA Octapeptide


Ac-TVASSSTA Octapeptide  的详细介绍

Product Description

Ac-TVASSSTA Octapeptide


Ac-TVASSSTA is an Octapeptide mimic of the N-terminal residues of the reactive center loop of PAI-1 (cf. P14-P7 residues). The Octapeptide inactivates PAI-1 by substituting for strand 4 in beta-sheet A in a manner that competes with formation of the latent species. Insertion of the peptide into beta-sheet A effectively forms a stable complex that converts PAI-1 into a substrate for tissue-type plasminogen activator (tPA) and other target proteinases. The resulting species of PAI-1 is thermodynamically stable and is useful for investigating the role of reactive center loop insertion. Supplied as a lyophilized powder. Add deionized water to original volume, aliquot and freeze unused portion.

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