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WSU Monoclonal Antibody Center
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In the mid 70s, a group of investigators demonstratedin mice that it is possible to immortalize B lymphocytes producing singlemonospecific antibodies (mAbs) by fusing B lymphocytes to tissue cultureadapted myeloma (malignant form of an antibody producing cell) cells. Thehybrid cells (hybridomas) were stable and could be maintained in cultureindefinitely or preserved in liquid nitrogen for later use. Thesefindings represented a major breakthrough in the way antibody reagentscould be developed for basic and biomedical research. Mice could beimmunized with antigens of interest and then used as a source of B lymphocytesto produce mAbs of known specificity. The spleen was shown to be the bestsource of B lymphocytes for making hybridomas. Hybridomas producing thedesired mAbs could be identified by examining culture medium from primarycultures of fused cells. In subsequent investigations, myeloma fusion partnerswere developed that could only grow in selective growth medium if fused toa B lymphocyte, eliminating the problem of distinguishing hybridomas fromcells that had not fused with a B lymphocyte. Myeloma fusion partners werelater identified that could no longer produce their own antibody but couldproduce antibody derived from the B lymphocyte. These advances simplifiedand improved the methodology for producing mAbs.
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