品牌名称——
Diarect
品牌logo——
品牌介绍——
The Quality League of Immunodiagnostic Components
Established in 1998, DIARECT AG is a privatelyowned biotech company with expertise in developing and establishingstandardized large-scale productions of both recombinant and native proteins,including their worldwide distribution. Providing customers with products andservices of consistent quality is one of the cornerstones of DIARECT’s businessphilosophy. DIARECT is not only a leading manufacturer of autoimmune and infectious diseaseantigens, but also the European distributor of SurModics' protein stabilizationreagents and blockers and BioFX substrates. Therefore, DIARECT is able toprovide most of the critical components for the development of diagnostic endproducts. Research & Development Since its founding, DIARECT has been involved in numerous innovativeimmunodiagnostic assay developments:
First thyroid peroxidase antibody test system, based on recombinant TPO
First ANA/ENA profile and screening assay, utilizing several recombinant proteins
Most complete panel of recombinant Borrelia spp. antigens
Introduction of symmetrically dimethylated recombinant SmD proteins
Supply of infrequent antigens, e.g. EJ, KS, MDA5, TIF1 gamma
Driven by the commitment to further expand its range of products, DIARECT willstrive to continue the development of new antigens in the years to come. Manufacturing Experience With more than 15 years of experience in the production of immunoassays,DIARECT has identified that test performances directly correlate with a sophisticatedassay development process and high-quality components. In order to minimizevariances during manufacturing processes all components need to be available insufficient amounts and reproducible qualities. The production of lots of largesizes and lot-to-lot consistency is DIARECT’s expertise. Innovation Innovation is the creative result of basic and applied research. In order togenerate superior product performance, DIARECT endeavors to combine intensivefirst-class research experience with formative years of practical experience inimmunodiagnostic manufacturing. Committed to Clinical Science Aiming to enhance assay performance, DIARECT provides superior components foran improved level of assay quality. This concept includes the support of immunologistsworldwide, scientific collaborations, and an ongoing academic involvement
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30301
DFS70
1.0 mg
13000
U1-snRNP 68/70 kDa
0.1 mg
13001
13100
U1-snRNP A
13101
13200
U1-snRNP C
13201
13300
U-snRNP B/B‘
13301
17500
Sm (non recombinant; bovine)
17501
Sm (非重组; 牛)
11600
RNP /Sm (non recombinant; bovine)
11601
RNP/Sm (非重组; 牛)
11700
SmD
11701
11800
SmD1
11801
11900
SmD2
11901
12000
SmD3
12001
12300
dsDNA (plasmid)
12301
14100
Ribosomal Phosphoprotein P0
14101
核糖体磷蛋白 P0
14200
Ribosomal Phosphoprotein P1
14201
核糖体磷蛋白 P1
14300
Ribosomal Phosphoprotein P2
14301
核糖体磷蛋白 P2
15400
Proliferating Cell Nuclear Antigen (PCNA)
15401
增殖细胞核抗原 (PCNA)
17300
Ku (p70/p80)
17301
19700
Nucleolin
19701
17400
Ro/SS-A (60 kDa; recombinant)
17401
Ro/SS-A (60 kDa; 重组)
15500
Ro/SS-A (60 kDa; non recombinant; bovine)
15501
Ro/SS-A (60 kDa; 非重组; 牛)
12700
Ro/SS-A (52 kDa)
12701
12800
La/SS-B
12801
12500
Centromere Protein B (CENP-B)
12501
着丝粒蛋白 B
16900
Centromere Protein A (CENP-A)
16901
着丝粒蛋白 A
12400
DNA Topoisomerase I (Scl-70; full length)
12401
DNA 拓扑异构酶 I (Scl-70; 全长)
14500
DNA Topoisomerase I (Scl-70; truncated)
14501
DNA 拓扑异构酶 I (Scl-70; 截短的)
11500
DNA Topoisomerase I (Scl-70; non recombinant; bovine)
11501
DNA 拓扑异构酶 I (Scl-70; 非重组; 牛)
16000
PM/Scl 100
16001
17000
PM/Scl 75
17001
12900
Histidyl-tRNA Synthetase (Jo-1)
12901
组氨酰-tRNA合成酶 (Jo-1)
15600
Threonyl-tRNA Synthetase (PL-7)
15601
苏氨酰-tRNA合成酶 (PL-7)
15700
Alanyl-tRNA Synthetase (PL-12)
15701
丙氨酰-tRNA合成酶 (PL-12)
11100
Glycyl-tRNA Synthetase (EJ)
11101
甘氨酰-tRNA合成酶 (EJ)
30100
Asparaginyl-tRNA Synthetase (KS)
30101
天冬氨酰-tRNA合成酶 (KS)
18400
SRP54
18401
信号识别颗粒的 54kDa 亚基
18100
Mi-2
18101
11000
TIF1 gamma
11001
30000
MDA5
30001
12100
Thyroid Peroxidase (TPO)
12101
甲状腺过氧化物酶
12200
Thyroglobulin (non recombinant)
12201
甲状腺球蛋白(非重组)
15200
Tissue Transglutaminase (tTG;expressed in Baculovirus/Sf9)
15201
14400
Tissue Transglutaminase (tTG;expressed in E. coli)
14401
19500
Gliadin (recombinant; deamidated)
19501
19800
Cytochrome P450 2D6 (LKM 1 hp)
19801
细胞色素 P450 2D6 (抗肝肾微粒体 1 型; LKM 1 hp)
44901
Candida albicans Met6
48000
Parvovirus B19 VLP VP2
0.1 mg Parvovirus B19 VLP VP2
48001
48100
0.1 mg Parvovirus B19 VLP VP1/VP2 Co-Capsid
48101
44500
Streptococcus pyogenes Arginine Deiminase (arcA)
44501
44600
Streptococcus pyogenes Transketolase (tkt)
44601
43000
Yersinia enterocolitica (O:8) YopM
43001
43100
Yersinia enterocolitica (O:9) LcrV
43101
43300
Yersinia enterocolitica (O:9) YopD
43301
43400
Yersinia enterocolitica (O:9) YopH
43401
43500
Yersinia enterocolitica (O:9) YopM
43501
43600
Yersinia enterocolitica (O:9) YopN
43601
13700
Formiminotransferase Cyclodeaminase (LC 1)
13701
亚胺甲基转移酶氨基环化酶 (抗肝细胞胞质 1 型抗体; LC 1)
18000
M2
18001
抗线粒体抗体
17700
BCOADC-E2
17701
17800
OGDC-E2
17801
17900
PDC-E2
17901
18900
Sp100
18901
19000
gp210
19001
19400
Nup62
19401
18500
Myeloperoxidase (MPO; non recombinant)
18501
髓过氧化物酶(MPO; 非重组)
18600
Proteinase 3 (PR3; non recombinant)
18601
蛋白酶 3 (PR3; 非重组)
19200
BPI (non recombinant)
19201
BPI (非重组)
14900
?2-Glycoprotein 1 (Apolipoprotein H)
14901
?2-糖蛋白 I (载脂蛋白 H)
11300
?2-Glycoprotein 1 (Apo H; non recombinant; human)
11301
?2-糖蛋白 I (载脂蛋白 H; 非重组; 人)
11400
?2-Glycoprotein 1 (Apo H; non recombinant; bovine)
11401
?2-糖蛋白 I (载脂蛋白 H; 非重组; 牛)
16800
Glomerular Basement Membrane (GBM; dissociated)
16801
肾小球基底膜 (GBM; 裂解的)
13800
Glutamate Decarboxylase 65 kDa (GAD65)
13801
谷氨酸脱羧酶 65 kDa (GAD65)
16700
Intrinsic Factor
16701
内因子
19600
GP2**
19601
50500
Gly m 4.0101
50501
50600
Gly m 5.0101
50601
51300
Phl p 1.0102
51301
51400
Phl p 2.0101
51401
51500
Phl p 5.0203
51501
51600
Phl p 6.0101
51601
50700
Aln g 1.0101
50701
50800
Aln g 4.0101
50801
50200
Bet v 1.0101
50201
50300
Bet v 2.0101
50301
51200
Car b 1.0109
51201
51100
Cor a 1.0103
51101
50900
Fra e 1.0101
50901
44200
Babesia microti IRA
44201
44100
Babesia microti p32
44101
41100
Borrelia afzelii BmpA
41101
40900
Borrelia afzelii DbpA
40901
41000
Borrelia afzelii OspA
41001
41800
Borrelia afzelii OspC
41801
42300
Borrelia afzelii p100
42301
40500
Borrelia burgdorferi BmpA
40501
40400
Borrelia burgdorferi DbpA
40401
40600
Borrelia burgdorferi DbpB
40601
41300
Borrelia burgdorferi NapA
41301
41200
Borrelia burgdorferi OspA
41201
40300
Borrelia burgdorferi OspC
40301
40100
Borrelia burgdorferi p100
40101
40200
Borrelia burgdorferi p41
40201
41500
Borrelia burgdorferi p45
41501
41600
Borrelia burgdorferi p58
41601
41700
Borrelia burgdorferi p66
41701
41900
Borrelia garinii OspC
41901
40700
Borrelia garinii p58
40701
41400
Borrelia garinii VlsE1
Diarect是一家提供诊断试剂原料的高科技企业。公司成立于1998年,是有着20多年自身抗原研发经验的Liedvogel教授和Hanbruck博士联手创建。1993年Haubruck博士利用杆状病毒/Sf9昆虫细胞表达系统成功的研发出人重组抗原--TPO,6年后Diarect是**家将人重组TPO引进体外诊断市场的公司。
为我们的客户提供稳定高质量的产品与服务是Diarect的根本理念之一。Diarect分别在2002年和2008年通过了ISO9001:2000和ISO13485:2003质量管理体系认证。在过去20年里,Diarect的专家们始终致力于自身免疫抗原的研发与生产。致病自身抗原的面世有助于我们了解自身免疫疾病的发病机制,为疾病的早期诊断及病程监控提供了有力的依据。
Diarect主要生产人重组抗原,用于自身免疫性疾病的体外诊断。杆状病毒/昆虫细胞表达系统凭借其高表达水平及翻译后修饰功能而被普遍用于表达大规模外源蛋白。通过杆状病毒/昆虫细胞表达的人重组蛋白具有很高的生物活性,其抗原性、免疫原性与人的天然蛋白相似,而从动物中获得的天然蛋白与人天然蛋白存在一定的差异。由于天然蛋白的资源有限、来源各异,导致天然纯化的抗原纯度低、批次之间不一致。而我公司生产的重组抗原纯度高,保证各批次之间的一致性。有些自身抗原标靶是由多个蛋白质或复合物组成。由于蛋白质空间结构的阻碍,单一蛋白也学不能被检测到。重组蛋白的面世使检测单一蛋白成为可能(例如:U1-snRNP Protein A,U1-snRNP Protein C和U1-snRNP Protein 68/70kDa等。
Diarect生产的抗原在质量和灵敏度方面有很好的口碑。以高质产品为理念的实验室设计以及先进**的设施时我们满足国际质量标准和客户特定要求的关键。
德国 DIARECT公司 成立于1998年,是开发建立标准化大规模生产重组和天然蛋白的生物技术企业,主要生产人重组抗原,用于自身免疫性疾病的体外诊断。为客户提供稳定高质量的诊断试剂原料产品和服务是DIARECT经营的根本理念之一。Diarect分别在2002年和2008年通过了ISO9001:2000和ISO13485:2003质量管理体系认证。
丰富制造经验
DIARECT深知免疫试验结果与复杂的试验开发过程和高品质的组分相关,为了在生产过程中*大限度地减少方差,所有的组件需要提供足够的数量和可重复的品质。DIARECT拥有超过15年生产免疫试剂经验,专业生产各种大包装,并且保证各个批次间的稳定性。
致力**科学
旨在提高试验的性能,DIARECT提供优异的组分用于试剂质量的改进,当然这还包括全世界的免疫学家支持,科研合作和持续的学术交流。在过去20年里,Diarect的专家们始终致力于自身免疫抗原的研发与生产,致病自身抗原的面世有助于我们了解自身免疫疾病发病机制,为疾病的早期诊断及病程监控提供有力依据。
参与了众多**免疫诊断试验研发:
**个基于重组血小板生成素TPO的甲状腺过氧化物酶抗体检测系统
**个利用多种重组蛋白的ANA/ ENA筛选试验,
针对重组疏螺旋体抗原的*完整的组合试剂
引进对称的二甲基化重组SMD蛋白
罕见的抗原供应,如EJ,KS,MDA5,TIF1 gamma等
为进一步扩大其产品范围,DIARECT将继续新抗原的开发。
DIARECT公司的产品涉及以下几个方面:
自身免疫甲状腺疾病
混合性结缔组织病/系统性红斑狼疮
系统性红斑狼疮/ dsDNA /人单克隆dsDNA标准品
干燥综合症/系统性红斑狼疮
系统性硬化病/肢端硬皮综合症
多发性肌炎/皮肌炎
系统性红斑狼疮-其他的标记物
麸质过敏症
中性粒细胞特异性自身抗体相关疾病
自身免疫性肝炎/原发性胆汁性肝硬变
抗磷脂综合症/血栓栓塞综合症
恶性贫血
其他产品等
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