Anti-Nestin Antibody

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产品名称: Anti-Nestin Antibody

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产品展商: ABM

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Anti-Nestin Antibody

Anti-Nestin Antibody 的详细介绍

Overview	Print Version
Product Name	Anti-Nestin Antibody
Description	Nestin, is a large intermediate filament protein (class Type VI) that was first identified with a monoclonal antibody by Hockfield and McKay (1985). Nestin is expressed predominantly in stem cells of the central nervous system in the neural tube. Nestin is expressed during development and in myotendinous and neuromuscular junctions. Nestin expression is restricted, typically disappearing by E18. Nestin is thought to be a reasonable neuronal marker; however, recent studies have found nestin expression in other cell types such as endothelial cells. Nestin expression is seen in almost all GBMs (Glioblastoma mulitformes) and many melanomas (both primary and metastatic) but not in any metastatic carcinomas. Upon terminal neural differentiation, nestin is downregulated and replaced by neurofilaments.
Subtype	polyclonal
Application	WB, ELISA, Other,
Raised In	Rabbit
Specificity	This affinity purified antibody is directed against human Nestin protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross reactivity with Nestin protein from human and macaque (100% homology). Based on protein sequence homology also expect partial reactivity against Nestin homologues from rabbit (94%), mouse (reactivity shown above), rat and hamster (88%), and bovine and dog (82%). Reactivity against homologues from other sources is not known.
Immunogen	This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein corresponding to amino acids 1484-1500 of human Nestin protein.
Guarantee	abm guarantees that all our Anti-Nestin Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Properties
Formulation	Liquid
Quantity	100 μg
Clone	Polyclonal
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Buffer	PBS, pH 7.4 with 0.05% sodium azide.
Concentration	1µg/ul
Purity	Affinity Purified
Isotype	IgG
Species Reactivity	human, rat, other
Anti-Nestin Antibody Images

Specific References
Y050405 has been referenced in 1 publication. Dahlstrand,J., Zimmerman,L.B., McKay,R.D. and Lendahl,U. (1992) Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments. J. Cell. Sci. 103 (Pt 2), 589-597. Yaworsky,P.J. and Kappen,C. (1999) Heterogeneity of neural progenitor cells revealed by enhancers in the nestin gene. Dev. Biol. 205 (2), 309-321. Hockfield,S. and McKay,R.D. (1985) Identification of major cell classes in the developing mammalian nervous system. J. Neurosci. 5 (12), 3310-3328. Mokry,J., Cizkova,D., Filip,S., Ehrmann,J., Osterreicher,J., Kolar,Z. and English,D. (2004) Nestin expression by newly formed human blood vessels. Acta Neurochir. Suppl. 13 (6), 658-664. Aihara,M., Sugawara,K., Torii,S., Hosaka,M., Kurihara,H., Saito,N. and Takeuchi,T. (2004) Angiogenic endothelium-specific nestin expression is enhanced by the first intron of the nestin gene. Lab. Invest. 84 (12), 1581-1592.

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