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mNanog Adenovirus (Mouse)

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产品名称: mNanog Adenovirus (Mouse)
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产品展商: ABM
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mNanog Adenovirus (Mouse)


mNanog Adenovirus (Mouse)  的详细介绍
Print Version
Vector pAdeno
Promoter CMV
Insert mNanog
Picture
Organism Mouse
Accession # Q80Z64
Alias Ecat4, Enk
Protein Type Wild Type
Protein Family Belongs to the Nanog homeobox family.
Functions Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, promotes cells to enter into S phase and proliferation. The product can be used in combination with other iPSC factor for the induction of iPSC reprogramming.
Protein Location Nucleus
Gene Type cDNA
Purification By Ion-Exchange column.
Quality Control By sequencing and Western blot analysis of transgene expression in transduced cells. Functional test includes iPSC reprogramming.
Titer >1x106pfu/mL
Storage 10 mM Tris-HCl, pH 8.0
Shipping High titer adenoviruses are shipped with dry ice and low titer adenoviruses are shipped with ice packs. For long term storage, it is recommended to store the viruses at -80°C in small aliquots to avoid repeated freeze-thaw cycles.
Notes For Research Use Only, not for therapeutic or diagnostic purposes.
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